Celecoxib effervescent tablet and preparation method thereof

A technology for celecoxib and effervescent tablets, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. It solves the problems of long time and large proportion of excipients, and achieves the effect of improving medication compliance, convenient taking and fast absorption.

Active Publication Date: 2013-08-07
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Ordinary tablets of celecoxib take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of celecoxib. to play

Method used

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  • Celecoxib effervescent tablet and preparation method thereof
  • Celecoxib effervescent tablet and preparation method thereof
  • Celecoxib effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0034] prescription:

[0035]

[0036] Preparation:

[0037] (1) Mix celecoxib powder (200 mesh) and sucrose powder (150 mesh) in equal increments to obtain mixture A;

[0038] (2) After passing the remaining excipients through a 200-mesh sieve, mix them evenly in equal increments to obtain mixture B;

[0039] (3) After mixing the mixture A and the mixture B in equal increments, press the tablets directly.

Embodiment 2

[0041] prescription:

[0042]

[0043] Preparation:

[0044] (1) Mix celecoxib powder (200 mesh) and lactose powder (150 mesh) in equal increments to obtain mixture A;

[0045] (2) After passing the remaining excipients through a 200-mesh sieve, mix them evenly in equal increments to obtain mixture B;

[0046] (3) After mixing the mixture A and the mixture B in equal increments, press the tablets directly.

Embodiment 3

[0048] prescription:

[0049]

[0050]

[0051] Preparation:

[0052] (1) Mix celecoxib powder (200 mesh) and lactose powder (150 mesh) in equal increments to obtain mixture A;

[0053] (2) After passing the remaining excipients through a 200-mesh sieve, mix them evenly in equal increments to obtain mixture B;

[0054] (3) After mixing the mixture A and the mixture B in equal increments, press the tablets directly.

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PUM

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Abstract

The invention discloses celecoxib effervescent tablets which are used for treating rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The tablets can also be used for treating acute pain, dysmenorrhea, colorectal polyps and post-operative analgesia, lower back pain, shoulder periarthritis and tenosynovitis. According to the invention, celecoxib is adopted as a raw material, and auxiliary materials are added, such that the celecoxib effervescent tablets are prepared. The celecoxib effervescent tablets have the advantages of fast disintegration, fast absorption high bioavailability, convenient application, low intestinal residue, low side effect, and sweet taste and good fragrance. With the tablets and the method, patient medication compliance can easily be improved.

Description

Technical field [0001] The invention relates to a new dosage form of celecoxib, in particular to celecoxib effervescent tablets and a preparation method thereof. Background technique [0002] Celecoxib is a blockbuster drug developed and sold by Pfizer. It is mainly used to treat rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is also used to treat acute pain, dysmenorrhea, colorectal polyps and post-operative analgesia. Pain etc. Celecoxib was again approved for lower back pain, frozen shoulder and tenosynovitis in 2007. Celecoxib is used for traumatic pain and pain after tooth extraction is in Phase III clinical trials, and it is also under study for the treatment of various tumors including breast cancer, lung cancer and pancreatic cancer. The latest domestic and international epidemiological, clinical and experimental studies show that celecoxib also has the effect of preventing and inhibiting tumors. Because of its strong targeting and low side effects...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/415A61K47/46A61P29/00A61P19/02A61P19/08A61P1/00A61P35/00
Inventor 王超志
Owner GUIZHOU LIANSHENG PHARMA
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