Liquid chromatograph, sample introduction device for liquid chromatograph, and method for cleaning sample introduction device for liquid chromatograph
A liquid chromatography and introduction device technology, applied in the direction of sampling devices, measuring devices, instruments, etc., can solve the problems of longer time, achieve the effect of improving separation, high sensitivity, and preventing longer analysis time
Inactive Publication Date: 2013-08-07
HITACHI HIGH-TECH CORP
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Problems solved by technology
On the other hand, since other means and processes for cleaning the inside of the needle are required, the time required for sample injection is longer than that of the direct sample injection method.
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[0044] figure 1 It is a schematic configuration diagram of a liquid chromatograph using an automatic sample introducing device of a quantitative loop sampling method as an embodiment of the present invention. The sample holding container 1 is set on the sample rack 14 . The needle 2 moves between the sample holding container 1 , the cleaning tank 10 , and the sample injection port 3 of the sampling valve 8 at the port 2 position of the sample holding container 1 , not shown, by a needle moving mechanism not shown.
[0045] The injection valve 8 with 6 ports and 2 positions has 6 ports and a flow path connecting two of the adjacent ports. As shown in the figure, at the injection position, port P1 and port P6, port P2 and port P3, and port P4 and port P5 are connected. In addition, the pump device 7 is connected to the port P1, the column 6 is connected to the port P2, the sample retention ring 5 is connected between the port P3 and the port P6, the sample injection port 3 is ...
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Disclosed is a liquid chromatograph provided with: a first flow path switching means which switches between connection of a sample storage loop to a mobile phase flow path and separation of the sample storage loop from the mobile phase flow path; a needle which suctions and discharges a sample; a weighing means which performs suction and discharge of the sample to the needle while weighing the sample; a cleaning solution feeding means which feeds a cleaning solution; a second flow path switching means which switches between at least two types of cleaning solutions; a third flow path switching means which switches between connection of the needle and the weighing means and connection of the needle and the cleaning solution feeding means; and a control means which controls operation of the first flow path switching means, the weighing means, the cleaning solution feeding means, the second flow path switching means, and the third flow path switching means, wherein the total amount of the sample is injected into the sample storage loop and the cleaning solution is injected into a flow path from the sample storage loop to a sample inlet.
Description
technical field [0001] The present invention relates to a liquid chromatograph, a sample introduction device for the liquid chromatograph, and a cleaning method for the sample introduction device for the liquid chromatograph. Background technique [0002] In a liquid chromatograph, which is a type of liquid sample analysis device, a mobile phase (eluent) is sucked by a pump device, and the mobile phase is sent to a column together with a sample introduced by an automatic sample introduction device. The sample introduced into the column is separated into components and detected by various detectors. Generally, in the field of devices called high-speed liquid chromatography (HPLC), analysis is required to be performed under a high pressure of 20 MPa to 40 MPa at the most. In such a pump device for HPLC, it is required that the mobile phase can be supplied accurately and precisely even under high pressure. [0003] In addition, the automatic sample introducing device is a dev...
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IPC IPC(8): G01N30/26G01N30/20G01N30/24
CPCG01N35/1004G01N30/24G01N1/02G01N35/1095
Inventor 铃木裕志石井公彦植田充彦清水克敏关良明
Owner HITACHI HIGH-TECH CORP