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Lignan compounds from Schisandra schisandrae and method for obtaining them

A technology of Schisandra chinensis and compounds, applied in the fields of active ingredients of heterocyclic compounds, cosmetics, food science, etc., can solve the problems of imperfect skin whitening effect, limited use, strong skin irritation, etc., and achieve excellent skin whitening effect Effect

Inactive Publication Date: 2017-09-05
AMOREPACIFIC CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Therefore, substances such as ascorbic acid, kojic acid, arbutin, hydroquinone or derivatives thereof are generally considered to have skin whitening effects to treat or alleviate skin pigmentation caused by excessive melanin production, but these The skin whitening effect of the substance is not perfect, but the skin irritation is strong and the use is limited

Method used

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  • Lignan compounds from Schisandra schisandrae and method for obtaining them
  • Lignan compounds from Schisandra schisandrae and method for obtaining them
  • Lignan compounds from Schisandra schisandrae and method for obtaining them

Examples

Experimental program
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Effect test

Embodiment

[0045] Get Southern Schisandra Lignan F

[0046] Using 95% ethanol at a temperature of 70-75°C, the Schisandra chinensis (30kg) was repeatedly extracted three times for two hours to obtain the Schisandra schisandra extract (2640g). The volumes of 95% ethanol used in three extractions were 150L, ​​150L and 120L, respectively. After the obtained Schisandra chinensis extract was dissolved in water, one or more solvents were selected from solvents with a solvent polarity index (PolarityIndex) between 2 and 9, and fractions of each solvent were respectively obtained. Among them, the solvent fraction with a polarity index (Polarity Index) between 2.5 and 4.5 was separated by using a silica gel column. The fractionation solution uses a mixed solvent of petroleum ether (Petroleum ether) and ethyl acetate (EtOAc) with a volume ratio of 100:0~0:100, and a total of ten fractions are obtained as a result of fractionation. Among them, the solvent fraction with the volume ratio of petrole...

experiment example

[0050] Evaluation of skin whitening effect of lignan F from Schisandra genus

[0051] Put the rat melanocyte cell line melan-a in RPMI 1640 (Gibco BRL, NY, USA) medium, and then add 10% heat-inactivated bovine serum (FBS, Gibco BRL, NY, USA) , 100 mg / mL penicillin potassium, 100 mg / mL streptomycin sulfate (Gibco BRL, NY, USA) and PMA (Sigma-Aldrich, St Louis, MO, USA) cell culture medium. Melan-a cell culture is in 48-well plate, according to 1.5X10 4 After seeding cells / well, in 10% CO 2、 Incubate in cell culture medium at 37°C for 24 hours. Then, the cell culture medium containing 0.3 ppm, 0.6 ppm, 1.25 ppm, 2.5 ppm or 5 ppm of Schisandra lignans F obtained in Examples were treated and cultured for six days. And 50ppm arbutin was used as a positive control group, and the cell culture medium containing Schisandra lignans F or arbutin was replaced every three days. The solvent was diluted 1 / 1000 in cell culture medium with DMSO. After culturing, remove the medium, wash ...

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Abstract

The invention discloses a skin-whitening lignin compound and its salt and a method for obtaining the lignin compound or its salt from Kadsura coccinea(Lem.)A.C.Smith.

Description

technical field [0001] The invention relates to a lignan compound with skin whitening effect and its obtaining method. Background technique [0002] Human skin color depends on many factors such as the activity of melanocytes that produce melanin on the surface of the skin, the distribution of blood vessels, the thickness of the skin, or whether carotenoids and bilirubin contain pigments. In particular, the level of formation of melanin, which is melanin produced from melanocytes under the action of many enzymes such as tyrosinase, is one of the most important factors in determining skin color. [0003] Melanin in the skin has the function of protecting the body from ultraviolet rays, but too much melanin can also cause moles, freckles, spots, age spots, etc., making the complexion dull, and even promote skin aging and induce skin cancer. . [0004] Therefore, substances such as ascorbic acid, kojic acid, arbutin, hydroquinone or derivatives thereof are generally considere...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49C07D493/18A61Q19/02
CPCA23L33/10A23L33/105A23V2002/00A23V2200/318A61K8/498A61K8/9789A61K31/36A61K36/79A61Q19/02C07D493/22
Inventor 成亮孔德云金东泫赵嘉英高明辰文诚浩廉明勳曺浚喆何泉泉河正喆延在昊
Owner AMOREPACIFIC CORP
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