Application of lycorine compounds in the preparation of antitumor drugs

A compound, the technology of lycorine, applied in the field of lycorine compounds, can solve the problems such as the unknown mechanism of action
CN103304573BInactive Publication Date: 2016-01-06NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2016-01-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to application of a Lycorine compound in anti-tumor drugs, and also relates to application of its various optical isomers, pharmaceutically acceptable salts, solvates and prodrugs in preparation of anti-tumor drugs. The invention also relates to application of pharmaceutical compositions containing the Lycorine compound with a structure shown as formula (A) in preparation of anti-tumor drugs.
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Description

technical field

[0001] The present invention relates to lycorine compounds, pharmaceutical compositions, synthesis methods and preparation methods of such compounds. Specifically, the present invention provides a class of lycorine compounds, a pharmaceutical composition containing the compounds and an anti-tumor application of the compounds. Background of the invention

[0002] Lycoris Herb (Lycoris Herb) belongs to the monocot class Amaryllidaceae (Amarylllidaceae), and there are more than 20 species in the world. Lycoris plants have long been used as medicinal plants to treat diseases and injuries. According to the "Compendium of Materia Medica" records: Lycoris not only has multiple functions such as detoxification, expectoration, diuresis, and vomiting, but also can be used for sore throat, carbuncle, etc. Swelling sores, scrofula, edema, etc. Lycorine is an isoquinoline alkaloid, which was first isolated from the bulb of Lycoris in 1895. It has anti-inflammatory, anti...

Claims

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