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Beta-cyclodextrin/carboxymethyl chitosan medical dressing and preparation method thereof

A technology of carboxymethyl chitosan medicine and carboxymethyl chitosan is applied in the field of β-cyclodextrin/carboxymethyl chitosan medical dressing and its preparation, and can solve the problems of poor adhesion, easy falling off and mechanical strength. Insufficient, increase infection rate and other problems, to achieve the effect of increasing solubility, simple preparation method and stable process

Inactive Publication Date: 2013-09-25
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biological dressings currently used clinically are mainly collagen-based hemostatic agents and oxidized cellulose, which have more or less deficiencies, such as insufficient mechanical strength and easy residue, easy to cause allergic reactions and increase infection rate, poor adhesion and easy to fall off, etc. Difficult to meet clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The β-cyclodextrin / carboxymethyl chitosan medical dressing of the present embodiment is made up of following weight ratio raw material: 6 parts of carboxymethyl chitosan, 2 parts of comfrey-β-cyclodextrin clathrate, polyethylene 12 parts of alcohol and 20 parts of glycerin; wherein the comfrey-β-cyclodextrin inclusion complex is composed of the following raw materials in weight ratio: 2 parts of β-cyclodextrin and 2 parts of comfrey extract.

[0027] The preparation method of the β-cyclodextrin / carboxymethyl chitosan medical dressing of the present embodiment may further comprise the steps:

[0028] (1) Preparation of comfrey extract: take dried comfrey, crush it into coarse powder, soak it in 95% ethanol solution at room temperature for 30 minutes, place it in an ultrasonic cleaner for ultrasonic extraction for 30 minutes, filter it, and recover ethanol from the filtrate under reduced pressure Concentrate to a thick paste, which is Comfrey extract.

[0029] (2) Prepar...

Embodiment 2

[0038] The β-cyclodextrin / carboxymethyl chitosan medical dressing of the present embodiment consists of the following weight ratio raw materials: 40 parts of carboxymethyl chitosan, 20 parts of comfrey-β-cyclodextrin inclusion compound, polyethylene 30 parts of alcohol and 30 parts of glycerin; wherein the comfrey-β-cyclodextrin inclusion compound is composed of the following raw materials in weight ratio: 20 parts of β-cyclodextrin and 5 parts of comfrey extract.

[0039] The preparation method of the β-cyclodextrin / carboxymethyl chitosan medical dressing of the present embodiment may further comprise the steps:

[0040] (1) Preparation of comfrey extract: take dried comfrey, crush it into coarse powder, soak it in 95% ethanol solution at room temperature for 90 minutes, place it in an ultrasonic cleaner for ultrasonic extraction for 30 minutes, filter it, and recover ethanol from the filtrate under reduced pressure Concentrate to a thick paste, which is Comfrey extract.

[...

Embodiment 3

[0050] The β-cyclodextrin / carboxymethyl chitosan medical dressing of the present embodiment consists of the following weight ratio raw materials: 5 parts of carboxymethyl chitosan, 2 parts of comfrey-β-cyclodextrin inclusion compound, polyethylene 10 parts of alcohol and 20 parts of glycerin; wherein the comfrey-β-cyclodextrin inclusion complex is composed of the following raw materials in weight ratio: 2 parts of β-cyclodextrin and 1 part of comfrey extract.

[0051] The preparation method of the β-cyclodextrin / carboxymethyl chitosan medical dressing of the present embodiment may further comprise the steps:

[0052] (1) Preparation of comfrey extract: take dried comfrey, crush it into coarse powder, soak it in 95% ethanol solution at room temperature for 45 minutes, place it in an ultrasonic cleaner for ultrasonic extraction for 15 minutes, filter it, and recover ethanol from the filtrate under reduced pressure Concentrate to a thick paste, which is Comfrey extract.

[0053]...

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PUM

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Abstract

The invention discloses a beta-cyclodextrin / carboxymethyl chitosan medical dressing which comprises the following components in parts by weight: 5-50 parts of carboxymethyl chitosan, 2-20 parts of lithospermum-beta-cyclodextrin inclusion compound, 10-30 parts of polyvinyl alcohol and 20-30 parts of glycerol, wherein the lithospermum-beta-cyclodextrin inclusion compound is formed by including lithospermum extract through beta-cyclodextrin. The invention also discloses a method for preparing the medical dressing. The beta-cyclodextrin / carboxymethyl chitosan medical dressing can be used for fast haemostasis of traumatic bleeding, internal injury bleeding and the like, and has the effects of wound healing promotion, no irritation, high safety and the like.

Description

technical field [0001] The invention relates to the technical field of medical hemostatic dressings, in particular to a β-cyclodextrin / carboxymethyl chitosan medical dressing and a preparation method thereof. Background technique [0002] Uncontrollable trauma bleeding and wound infection lead to death of patients accounting for 30%-40% of trauma-related deaths. Early treatment of bleeding and control of wound infection are the main methods to reduce mortality. Traditional hemostatic dressings tend to adhere to skin wound tissue easily, often destroy new epithelium and granulation tissue when changing the dressing, cause bleeding, and make patients suffer from unbearable pain. The biological dressings currently used clinically are mainly collagen-based hemostatic agents and oxidized cellulose, which have more or less deficiencies, such as insufficient mechanical strength and easy residue, easy to cause allergic reactions and increase infection rate, poor adhesion and easy to...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/44
Inventor 潘娅莫文杰
Owner SOUTH CHINA UNIV OF TECH
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