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A technology of albendazole ivermectin powder and albendazole, which is applied in the field of wettable albendazole ivermectin powder and its preparation, can solve problems such as inconvenient use, and achieve improved dispersibility and increased Predator function, low production cost effect
Inactive Publication Date: 2015-07-15
CHENGDU QIANKUN VETERINARY PHARMA +1
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[0004] The present invention aims at the disadvantages of inconvenient use of existing compound products of avermectins and albendazole, and provides a wettable albendazole that can be uniformly dispersed in water and administered by drinking water or spraying on feed Vermectin powder
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Embodiment 1
[0025] Embodiment 1 Preparation of wettable albendazole ivermectin powder of the present invention
[0026] Take 10g of albendazole, 0.2g of ivermectin, 2.5g of magnesium stearate, 49.5g of powdered sugar, 9g of sodium lauryl sulfate, 2g of xanthan gum, 0.9g of fresh milk essence, 0.9g of sodium saccharin, Sodium citrate 25g, after above-mentioned raw material is mixed uniformly, pulverizes to 200 purpose fine powders, packs, obtains wettable albendazole ivermectin powder of the present invention.
Embodiment 2
[0027] Embodiment 2 Preparation of wettable albendazole ivermectin powder of the present invention
[0028] Take 8g of albendazole, 0.4g of ivermectin, 2g of magnesium stearate, 57g of powdered sugar, 7g of sodium lauryl sulfate, 4g of xanthan gum, 0.8g of fresh milk essence, 0.8g of sodium saccharin, citric acid 20g of sodium, after mixing the above raw and auxiliary materials evenly, pulverize to 200 mesh ultrafine powder, pack, and obtain the wettable albendazole ivermectin powder of the present invention.
Embodiment 3
[0029] Embodiment 3 Preparation of wettable albendazole ivermectin powder of the present invention
[0030] Take 6g of albendazole, 0.8g of ivermectin, 1.5g of magnesium stearate, 64.3g of powdered sugar, 5g of sodium lauryl sulfate, 6g of xanthan gum, 0.7g of fresh milk essence, 0.7g of sodium saccharin, Sodium citrate 15g, after above-mentioned starting and auxiliary material is mixed uniformly, pulverizes to 200 mesh ultrafine powders, packs, obtains the wettable albendazole ivermectin powder of the present invention.
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Abstract
The invention provides wettable albendazole ivermectin powder which is prepared from the following raw materials and auxiliary materials in parts by weight: 5-20 parts of albendazole, 0.1-1.6 parts of ivermectin, 0.5-3 parts of magnesium stearate, 33.9-70.7 parts of powdered sugar, 3-11 parts of sodium dodecyl sulfate, 0-8 parts of xanthan gum, 0.6-1 part of fresh milk essence, 0.6-1 part of saccharin sodium and 10-30 parts of sodium citrate. The invention also provides a preparation method and application of the wettable albendazole ivermectin powder. The wettable albendazole ivermectin powder significantly improves the dispersity of the ivermectin and albendazole in water to ensure that the ivermectin and the albendazole can be uniformly distributed in the water for a long time to facilitate clinical water drinking and administration; and the palatability of the albendazole ivermectin powder is greatly improved, and when used on faunas with sensitive tastes, such as pigs and the like, the albendazole ivermectin powder has a food calling function. The wettable albendazole ivermectin powder is simple in preparation process, low in production cost and suitable for industrial large-scale production.
Description
technical field [0001] The invention relates to a wettable albendazole ivermectin powder and a preparation method and application thereof. Background technique [0002] Since the 1940s, the research and development of anthelmintics has been extremely hot, during which gratifying results have been achieved; especially the discovery of Avermectins in 1976 opened a new era of anthelmintic research . The compound has a very strong repelling effect on nematodes and arthropods parasitic on animals, so that the dosage of anti-helminth drugs can be reduced from mg / kg level to μg / kg level. Currently commercialized drugs in this category include Avermectin (AVM), Ivermectin (IVM), Doramectin (DRM), and Eprinomectin (Eprinomectin, EPM, also known as iplemectin, apremectin), selamectin (Selamectin, SLM) and moxidectin (Moxidectin or Milbemycin, MXD, also known as moxidectin, moxidectin) and so on. Due to its excellent anthelmintic activity and high safety, abamectins are regarded as ...
Claims
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