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Application of chukrasone B in the preparation of drugs for preventing and treating liver damage
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A technology of liver damage and drugs, applied in the field of Chukrasone B, can solve problems such as liver damage, aggravation, and elevation, and achieve the effect of highlighting substantial characteristics and strong therapeutic effect
Active Publication Date: 2015-08-12
蚌埠中知知识产权运营有限公司
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4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver damage to varying degrees. The early manifestations of these liver damage are often Elevation of ALT (transaminase) or bilirubin, if the cause is not eliminated, the liver damage will be further aggravated
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Embodiment 1
[0010] Embodiment 1: the preparation of the compound Chukrasone B tablet involved in the present invention:
[0011] Take 20 grams of compound Chukrasone B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0012] Embodiment 2: the preparation of the compound Chukrasone B capsules involved in the present invention:
[0013] Get 20 grams of compound Chukrasone B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0014] The following pharmacodynamic experiments will further illustrate its drug activity.
[0015] The following are some pharmacological experimental data:
experiment example 1
[0016] Experimental example 1. The effect of Chukrasone B on preventing and treating liver injury
[0017] (1) Protective effect of Chukrasone B on D-galactosamine (D-GalN)-induced acute liver injury in mice
[0018] The mice were divided into 5 groups, and the control group was intragastrically administered with normal saline (0.3 mL·d -1 ), for 7 consecutive days, on the 7th day intraperitoneal injection of normal saline (0.15mL·10g -1 ); D-GalN, Chukrasone B (1.5, 3.0, 6.0 mg·kg -1 ) Each group was administered with normal saline and different concentrations of Chukrasone B (0.3mL·d -1 ), for 7 consecutive days, on the 7th day intraperitoneal injection of D-GalN (800mg·kg -1 , 0.15mL·10g -1 ), 16 hours later, blood was taken to measure AST and ALT activity.
[0019] Table 1 The protective effect of Chukrasone B on D-GalN-induced acute liver injury
[0020]
[0021] Note: 1) p2) p<0.01vs D-GalN group
[0022] It can be seen from Table 1 that Chukrasone B can effec...
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Abstract
The invention discloses an application of Chukrasone B in the preparation of medicines for preventing and treating liver damage. The pharmacological study on the Chukrasone B shows that the Chukrasone B has a protection effect on mice acute liver injury induced by D-galactosamine (D-GalN) and CC14. Therefore, the Chukrasone B can be used for the preparation of the medicines for preventing and treating liver damage or hepatitis. The application of the Chukrasone B in the medicines for preventing and treating liver damage is disclosed by the invention for the first time. As the skeleton type of the Chukrasone B belongs to a bran-new skeleton type and the Chukrasone B has an unexpected strong activity on liver damage treatment effect, the possibility that other compounds provide revelation does not exist. The Chukrasone B has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for treating liver damage.
Description
technical field [0001] The present invention relates to Chukrasone B, in particular to Chukrasone B used as medicine for preventing and treating liver damage. technical background [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutri...
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