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Medical application of gabapentin

A technology of gabapentin and its application, which is applied in the field of drugs used by gabapentin for the treatment of cerebral ischemia or cerebral infarction to achieve exact treatment and prevention effects, significant treatment and prevention effects, and effects of reducing sudden death rate

Inactive Publication Date: 2013-11-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of gabapentin in the treatment of cerebral ischemia or cerebral infarction in the prior art or clinical practice

Method used

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  • Medical application of gabapentin
  • Medical application of gabapentin
  • Medical application of gabapentin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 gabapentin tablet preparation

[0023]

[0024] Preparation process: Weigh the gabapentin, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix them evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 2

[0025] Embodiment 2 gabapentin tablet preparation

[0026]

[0027]

[0028] Preparation process: Weigh the prescribed amount of gabapentin, microcrystalline cellulose and hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 8% starch slurry, add it to the mixed powder, mix well and make soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 3

[0029] Embodiment 3 gabapentin tablet preparation

[0030]

[0031] Preparation process: Weigh the gabapentin, starch, dextrin and low-substituted hydroxypropyl cellulose in the prescribed amount and mix them evenly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly to make a soft material, granulated through a 16-mesh sieve, and dried below 60°C. After the drying is completed, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

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PUM

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Abstract

The application requests to protect an application of gabapentin for preparing a drug for treating or preventing ischemic cerebrovascular diseases, and belongs to the medicine field. Gabapentin is a conventional drug. According to the invention, a great many of experiments demonstrate that gabapentin can reduce NO and NOS level of an ischemic patient when the gabapentin is applied in the treatment of ischemic cerebrovascular diseases particularly cerebral ischemia or cerebral infarction, can reduce MDA content in serum, and has obvious protect effect for brain hippocampus neurons. The medical application of gabapentin can provide a novel drug selection of patients suffering from the ischemic cerebrovascular diseases, and has wide medical application prospects.

Description

technical field [0001] The invention relates to a medical application of the antiepileptic drug gabapentin, in particular to the application of gabapentin in medicine for treating cerebral ischemia or cerebral infarction, and belongs to the field of medicine. Background technique [0002] Ischemic cerebrovascular disease (ICVD) accounts for about 80% of all cerebrovascular diseases. It has the characteristics of high morbidity, disability and cure rate, and has become one of the diseases that seriously endanger human health. Ischemic cerebrovascular disease is a type of disease in which there is a sudden imbalance between the supply and demand of oxygen and other nutrients provided by local blood circulation and the metabolic needs of neurons, resulting in damage to neurons in the ischemic central area. Transient ischemic attack referred to as TIA, also known as transient ischemic attack or small stroke, it is due to the short-term insufficient blood supply of the arteries r...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61P9/10
Inventor 赵志全郁丽梅王洪臣
Owner LUNAN PHARMA GROUP CORPORATION
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