Method using 3D printing technology to prepare dropping pills

Abstract

The invention relates to a method using the 3D printing technology to prepare dropping pills. The method using the 3D printing technology to prepare the dropping pills comprises the steps of (1) using polyethylene glycol and the like as base materials, carrying out heating melting, (2) adding prescription drugs at the specified temperature, carrying out mixing, even stir and freeze drying to obtain solid powder, carrying out sieving on the solid powder, and (3) placing the solid powder into a powder box of a 3D printer, and preparing the dropping pills through electronic drafting, remote data transmission and laser scanning printing. According to the method using the 3D printing technology to prepare the dropping pills, due to the facts that through a series of technologies such as the electronic design technology, the remote data transmission technology, the laser scanning technology and the raw material and auxiliary material melting technology, the specific drug powder materials are melted, and electronic model graphs are changed into the real dropping pills according to designed indications, the advantages of the dropping method of preparing the dropping pills are kept, and the defects that due to the influence of the factors such as physical properties of liquid medicine, droppers and cooling liquid, pill weights are different, the roundness of pills is difficult to control, the percent of pass is low, and specially-shaped dropping pills cannot be easily prepared when the dropping method is used for preparation are overcome.

Description

technical field [0001] The invention belongs to the field of medical drugs, and relates to a method for preparing drop pills by using 3D printing technology, in particular to a method for preparing large-size drop pills and special-shaped drop pills. Background technique [0002] Dropping pills refer to solid or liquid medicines and appropriate substances (commonly referred to as substrates) that are heated, melted and mixed evenly, and then dropped into immiscible condensed liquids. of pills. Mainly for oral use, but also for topical and topical ear, nose, eye, rectal and vaginal use. [0003] The main features of drop pills are: fast dissolution rate, high bioavailability, and small adverse reactions; liquid drugs can be made into solid drop pills, which are easy to carry and take; increase the stability of drugs. It has been nearly 70 years since the drop pills came out, and its preparation technology, theory, equipment and varieties have greatly developed, as seen from...

AI Technical Summary

Problems solved by technology

[0004] Although the dripping pill has the above advantages, there are still some problems in the production process. For example, the main principle of the dripping pill machine is to use the gravity of the liquid to drip naturally from the mouth of the dripper, and then enter the cooling liquid to shrink into a pill.

There are many factors affecting the quality of the dropping pills. In addition to being mainly controlled by the thickness of the dropper caliber, it is also affected by the quality and temperature of the liquid medicine. In addition, the appearance and roundness of the product are also affected by the type of cooling liquid, Influenced by factors such as temperature, interfacial tension between liquid medicine and cooling liquid, there are problems in the industrial production of dripping pills, such as the difference in pill weight and the difficulty in controlling the roundness of the pills, the qualified rate of finished products is low, and the production cost is high, especially in the The problem is more prominent when producing large-scale dripping pills above 100mg