A kind of new lixistat pellet and preparation method thereof

A new technology of lixistat and pellets, which is applied in the field of medicine and food, can solve the problems of high cost, limited curative effect, easy sticking and punching of tablets, etc., and achieve the effect of convenient operation and simple preparation process

Active Publication Date: 2015-09-16
杭州高成生物营养技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this orlistat-containing preparation has a certain curative effect on obesity, it not only has the disadvantages of limited curative effect and high cost because it is a pancreatic lipase inhibitor, but also, because orlistat The melting point is low, and the tablet is easy to stick and punch, so there will be many problems in the preparation process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Preparation of ball core:

[0033] According to the percentage by weight of the ball core composition, get 50% filler: starch, 35% binder: microcrystalline cellulose and 15% disintegrant: low-substituted hydroxypropyl cellulose, and pulverize it into 80 mesh Put the above powder into a mixer, stir for 7 minutes, and mix thoroughly; add purified water with a ratio of sugar and purified water of 1:1 to make sucrose syrup as a binder.

[0034] When granulating, the powder supply machine is controlled at 50-100r / min, the liquid supply peristaltic pump is controlled at 60-120r / min, the main machine is controlled at 80-100r / min, the flow rate of the spray gun is controlled at 50-80ml / min, and the granulation time is controlled At 40min, temperature: controlled at 30°C. Through the granulator, the blank ball core with a particle size of Φ0.1-0.3mm is made into a nearly round shape, and the moisture content of the finished ball core is ≤4.0%.

[0035] 2. Pill core drug loa...

Embodiment 2

[0046] 1. Preparation of ball core:

[0047] According to the weight percentage of ball core composition, get 60% filler: starch, 30% binder: microcrystalline cellulose and 10% disintegrating agent: low-substituted hydroxypropyl cellulose, pulverize it into 80 mesh Put the above powder into a mixer, stir for 7 minutes, and mix thoroughly; add purified water with a ratio of sugar and purified water of 1:1 to make sucrose syrup as a binder.

[0048] When granulating, the powder supply machine is controlled at 50-100r / min, the liquid supply peristaltic pump is controlled at 60-120r / min, the main machine is controlled at 80-100r / min, the flow rate of the spray gun is controlled at 50-80ml / min, and the granulation time is controlled At 40min, temperature: controlled at 30°C. Through the granulator, the blank ball core with a particle size of Φ0.1-0.3mm is made into a nearly round shape, and the moisture content of the finished ball core is ≤4.0%.

[0049] 2. Pill core drug loadin...

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Abstract

The invention discloses a cetilistat pellet and a preparation method thereof. The pellet comprises a pill core, then the pill core is loaded with drugs to prepare a cetilistat drug-loaded pill, and finally the pill is coated with a gastric-soluble coating layer. The cetilistat pellet prepared by the preparation method not only effectively maintains the original properties of the citilistat, but also guarantees the quick and even dissolution of drugs, and the pellet is capable of being prepared into various common dosage forms in pharmacy.

Description

technical field [0001] The invention relates to a micropill with neolistat as the main component and a preparation method thereof, which is a good medicine for treating obesity and type II diabetes. It belongs to the technical field of medicine and food. Background technique [0002] With the improvement of people's living standards and the improvement and change of dietary ingredients, obesity has become a major disease affecting human health. At present, losing weight has not only become a fashion, but also an important way for people to ensure their physical and mental health. As a result, a wide variety of weight-loss drugs have emerged in the market, but their curative effects are all unsatisfactory. For this reason, the Chinese patent discloses a Chinese invention patent application dedicated to the treatment of obesity - a preparation containing orlistat and its preparation method (201110370659.2). The preparation uses orlistat as the main component, and is prepare...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/536A61K47/38A61P3/04
Inventor 冯利萍
Owner 杭州高成生物营养技术有限公司
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