Application of salix leaf and wintersweet extract in preparation of medicines for treating inflammatory bowel diseases and alleviating digestive tract damage caused by chemotherapy drugs

A technology of inflammatory bowel disease and chemotherapy drugs, applied in the field of medicine, can solve the problems of severe anti-tumor treatment, side effects, damage, etc.

Inactive Publication Date: 2013-11-27
LISHUI TONGZHOU MEDICAL & EDIBLE SOURCES TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Anticancer therapy is often accompanied by serious side effects, causing intestinal damage, which limits the application of drugs

Method used

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  • Application of salix leaf and wintersweet extract in preparation of medicines for treating inflammatory bowel diseases and alleviating digestive tract damage caused by chemotherapy drugs
  • Application of salix leaf and wintersweet extract in preparation of medicines for treating inflammatory bowel diseases and alleviating digestive tract damage caused by chemotherapy drugs
  • Application of salix leaf and wintersweet extract in preparation of medicines for treating inflammatory bowel diseases and alleviating digestive tract damage caused by chemotherapy drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation of willow leaf wintersweet water extract

[0020] Dried the fresh stems and leaves of wintersweet and crushed them, mixed the solid matter with water according to a certain mass-volume ratio, soaked for 0.5-2 hours, boiled for 5-30 minutes, filtered and discarded the residue, and the obtained supernatant was wintersweet water extract, and the water extract can be prepared into an extract after low-temperature freeze-drying or heating and vacuum concentration.

Embodiment 2

[0021] Example 2: Therapeutic effect of willow-leaved wintersweet on polyglucose sodium (DSS)-induced inflammatory bowel disease in mice

[0022] Dried the fresh stems and leaves of willow-leaved wintersweet and crushed them, mixed the solid matter with water at a mass-volume ratio of 4:25, soaked at room temperature for 1 hour, boiled for 10 minutes, filtered the dregs and obtained the supernatant as willow-leaved wintersweet Water extract.

[0023] Twenty C57 mice were randomly divided into 4 groups: normal control group, normal wintersweet group, model group and model wintersweet group. The IBD model was induced by replacing normal drinking water with 2% DSS aqueous solution for 5 days. During this period, the mice drank freely and replaced the new DSS solution every day. On the 5th day, DSS was replaced with normal drinking water; the drinking water was not replaced in the control group. After DSS was stopped, the mice were continuously gavaged for 4 days, each time wit...

Embodiment 3

[0034] Example 3: Therapeutic effect of the anti-cancer chemotherapeutic drug 5-fluorouracil (5-FU) induced mucositis in mice

[0035] Dried the fresh stems and leaves of Wintersweet and crushed them, mixed the solid matter with water at a mass volume ratio of 8:100, soaked for 2 hours, boiled for 10 minutes, filtered and discarded the residue, and the obtained supernatant was the water extract of Wintersweet. The product was prepared into an extract after low-temperature freeze-drying. The extract was dissolved in water to prepare different concentrations of water extract (CS) of wintersweet, corresponding to 0.25 g, 0.5 g, 0.75 g and 1 g of crude drug per ml of liquid.

[0036] Fifty-six C57 mice were randomly divided into 7 groups: normal control group, model group, model+positive drug group and model+Waterweed group (4 gradient concentrations). All mice were administered by intragastric administration for 13 days, twice a day, 0.1ml / 10g each time, the positive drug was ...

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Abstract

The invention relates to the technical field of medicines, and particularly relates to an application of a salix leaf and wintersweet extract in the preparation of medicines for treating inflammatory bowel diseases and alleviating digestive tract damage caused by chemotherapy drugs. The salix leaf and wintersweet extract is prepared from salix leaf and wintersweet through aqueous extraction, can be used for preparing the medicines for preventing and treating diseases such as diarrhea, enterogastritis and the inflammatory bowel diseases, assisting cancer chemotherapy and reducing the toxic and side effects of anti-tumor medicines and can be applied to the development of anti-mucositis and intestinal tract protection medicines.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a willow-leaved wintersweet extract in the preparation of medicines for treating inflammatory bowel disease and alleviating digestive tract damage caused by chemotherapy drugs. Background technique [0002] Wintersweet ( Chimonathus Salicifolius Hu ) is a plant of the genus Wintersweetaceae, a semi-evergreen shrub, named for its willow-like leaves. In my country, willow-leaved wintersweet is mainly distributed in Zhejiang, Anhui, Jiangxi and other places. The local She people in Lishui, Zhejiang often pick the stems and leaves to make soup, and call it "herbal tea". According to traditional experience, willow leaves and wintersweet soup has the effect of treating colds, abdominal pain, diarrhea, and indigestion. Our previous animal experiments have also shown that wintersweet can treat diarrhea symptoms in mice caused by senna leaves and castor oil, and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/00A61P1/12A61P1/04
Inventor 费俭刘震泽王维刚程舟王红兵
Owner LISHUI TONGZHOU MEDICAL & EDIBLE SOURCES TECH DEV
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