Liquid oral composition and method of stabilizing mixing components of the composition
A composition and oral cavity technology, which is applied in the directions of nursing oral cavity, pharmaceutical combination, medical preparations of inactive ingredients, etc., can solve the problems of difficult coexistence of palatability of preparations, ethanol stimulation, and difficulty in ensuring non-irritant stability over time at the same time, To achieve the effect of improved appearance stability and good palatability
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[0062] Hereinafter, although an Example, a comparative example, and a prescription example demonstrate this invention concretely, this invention is not limited to a following example. In addition, in the following examples, % represents mass % unless there is a particular limitation.
[0063] [Example, comparative example]
[0064] Liquid oral compositions of the compositions shown in Tables 1 to 4 were prepared by a usual method, and the following evaluations were performed. The results are shown in Tables 1-4.
[0065] (I) Tartar Adhesion Inhibition Effect
[0066] 2 mL of the liquid oral composition was injected into each of the 24-well plates, and three mirror-polished hydroxyapatite plates (radius 0.35 cm×height 0.35 cm, hereinafter referred to as HAP plates) manufactured by Pentax Co., Ltd. were immersed. )30 seconds.
[0067] Add 2 mL of buffer solution in which 10449 strains of Streptococcus mutans (Streptococcus mutans) are dispersed in a manner such that the turb...
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