Liquid oral composition and method for improving freeze recovery thereof

A composition and recovery technology, used in oral care, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as emulsification damage, no mention of freezing recovery, and achieve inhibition of irritation, excellent freezing recovery, high The effect of bactericidal power

Active Publication Date: 2019-08-09
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the composition of the emulsion, the water phase and the oil phase are in a mixed state through the emulsifier. Due to long-term storage, mechanical vibration, rapid temperature change, etc., the aggregation and coalescence of the emulsion are easy to occur. Emulsion destruction
The appearance of liquid preparations changes due to emulsification damage and causes quality problems. Although the above-mentioned patent documents also propose suggestions for improving storage stability, especially for those that have improved appearance recovery when frozen and thawed under low-temperature harsh conditions room
[0004] In addition, the above-mentioned patent documents do not mention the recoverability when frozen under low-temperature harsh conditions.

Method used

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  • Liquid oral composition and method for improving freeze recovery thereof
  • Liquid oral composition and method for improving freeze recovery thereof
  • Liquid oral composition and method for improving freeze recovery thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0056] A known method can be used for the preparation method of the emulsion.

[0057] For example, after mixing a specified amount of nonionic surfactant, polyol as a dispersant, and half an amount of water with a homogeneous mixer, add an oily component to form an emulsion, and finally add the remaining water to prepare O / W type emulsion. Thereafter, the prepared emulsion can be adjusted in average particle size using a high-pressure homogenizer.

[0058] In emulsification using a high-pressure homogenizer, the average particle size can be adjusted according to the difference in shear force. When the emulsified particles are micronized, the temporal stability is further improved. As the high-pressure homogenizer, a microfluidizer (manufactured by Microfluidic Technology International Co., Ltd. (Microfluidic Technology International Co., Ltd.)), a Gaulin homogenizer (manufactured by Rannie Gaulin), an ultimaizer (manufactured by Sugino Machinery Co., Ltd.) and the like can ...

Embodiment 1～18

[0100] [Examples 1-18, Comparative Examples 1-10]

[0101] The liquid oral compositions (mouthwashes) shown in Tables 1 to 4 were prepared by conventional methods, and the appearance stability (freeze recovery) during freezing and thawing, the refreshing feeling after use in the oral cavity, and the Is there any irritation. Moreover, about the liquid oral cavity composition which mixed isopropylmethylphenol shown in Table 3, 4, biofilm bactericidal ability was further evaluated by the following method. The results are collectively described in Tables 1-4.

[0102] In addition, the preparation method and composition of the emulsion used are as follows. The prepared emulsions A1 to A5 were mixed in the amounts shown in the table.

[0103]

[0104] An O / W type emulsion of the following composition was prepared by the following method. In addition, stirring using a homomixer uses a well-known high-pressure homogenizer (pressure condition 30-100 MPa), and the operation of pou...

Embodiment 19～24

[0185] The liquid oral compositions (mouthwashes) of Examples 19 to 24 shown in Table 5 were prepared in the same manner as above, and the appearance stability (freeze recovery) during freezing and thawing, and the stability after oral use were evaluated in the same manner as above. Refreshing feeling, irritating feeling during use, biofilm bactericidal ability, and whether there is a pungent taste during use are evaluated by the following methods. Moreover, the presence or absence of a pungent taste was evaluated similarly to Example 10 shown in Table 3, and the result is described in Table 5 together with the above-mentioned result.

[0186] In addition, the spices a to f used in Examples 19 to 24 all contain clove oil and thyme oil, and the contents of clove oil and thyme oil in the compositions of each example are shown in Table 5.

[0187] (5) Evaluation method for presence or absence of pungent taste during use

[0188] 10 evaluators contained 10 mL of each liquid oral ...

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Abstract

The present invention provides a liquid oral composition and a method for improving the freeze recovery of the liquid oral composition. The liquid oral composition has excellent appearance stability (freeze recovery) when frozen and thawed, and can also impart a good feeling of use. It contains an emulsion (A) and N-acyl taurate (B), wherein , the oily component of the emulsion (A) contains fats and oils that are liquid at 25° C., and the content of N-acyl taurate (B) is 0.2 to 0.8% by mass. Method for improving freeze recovery of the liquid oral composition Mixing 0.2 to 0.8% by mass of N-acyl taurate (B) in the liquid oral composition mixed with the emulsion (A), wherein the emulsion The oily component of liquid (A) contains fats and oils which are liquid at 25 degreeC.

Description

technical field [0001] The present invention relates to a liquid oral composition mixed with an emulsion and a method for improving its freeze recovery. The liquid oral composition has excellent appearance stability (freeze recovery) when frozen and thawed, and can also impart good sense of use. Background technique [0002] Conventionally, as a technique for mixing an emulsion into a liquid oral composition, a technique of mixing a specific emulsion in order to suppress ethanol stimulation of an ethanol mixed preparation has been proposed (Patent Document 1: Japanese Patent Application Laid-Open No. 2005-179231 ) , Improve the retention of medicinal ingredients and improve the technology of action (Patent Document 2: Japanese Patent Laid-Open No. 2005-179231, Patent Document 3: Japanese Patent Laid-Open No. 11-335253, Patent Document 4: Japanese Patent No. Publication No. 5043588, Patent Document 5: Japanese Patent Laid-Open No. 2011-168506, Patent Document 6: Japanese Pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/46A61K8/06A61K8/34A61K8/37A61K8/92A61Q11/00
CPCA61Q11/00A61K8/345A61K8/375A61K8/466A61K8/922A61K8/062A61K2800/21
Inventor 数野惠子赤羽康宏加藤妥治新仓祐司
Owner LION CORP
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