Novel anti-human IL-23 receptor antibody

A technology of IL-23R and antibody, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, anti-animal/human immunoglobulin, cells modified by introducing foreign genetic material, etc., can solve the problem Monoclonal antibodies are highly selective and not easy to achieve the effects of improving patient compliance, ensuring safety, and powerful immune cell suppression
CN103459426BActive Publication Date: 2015-05-13ASTELLAS PHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ASTELLAS PHARMA INC
Publication Date
2015-05-13

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Abstract

The present invention provides anti-human IL-23R antibodies with superior activity and / or species cross-reactivity compared with existing anti-human IL-23R antibodies, and various diseases that use the antibodies to prevent or treat human IL-23R involved in pathogenesis. way of disease. An anti-human IL-23R antibody, which respectively comprises the heavy chain variable region composed of the amino acid sequence shown in SEQ ID NO: 5, 9, 13, 17, 21, 25 or 29 and the amino acid sequence represented by SEQ ID NO: 7, 11, 15, 19, 23, 27 or 31 of the amino acid sequence shown in the light chain variable region.
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Description

Technical field

[0001] The present invention relates to a novel anti-human IL-23 receptor antibody. In detail, the novel anti-human IL-23 receptor antibody of the present invention is an anti-human IL-23 receptor with better activity and / or species cross-reactivity than existing anti-human IL-23 receptor antibodies antibody. Background technique

[0002] Interleukin-23 (also known as IL-23) is a cytokine produced by dendritic cells, etc. It is composed of 2 subunits (ie, p19 subunit unique to IL-23 and IL-12 also becomes its component The p40 subunit) is a heterodimeric cytokine (Non-Patent Document 1). IL-23 binds to IL-23 receptor (also referred to as IL-23R) to introduce signals into cells (Non-Patent Document 2). IL-23R is a heterodimeric receptor composed of the IL-23R subunit and the IL-12Rβ1 subunit which becomes a part of the IL-12 receptor. In addition, it is known that IL-12 receptor is a complex of IL-12Rβ1 subunit and IL-12Rβ2 subunit, and IL-23 does not bind to I...

Claims

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