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Pathogenic genes of schizophrenia and application

A technology for schizophrenia and disease-causing genes, applied in the field of genes

Inactive Publication Date: 2013-12-25
陈刚
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem that there is no schizophrenia-related pathogenic gene record in the above prior art, the present invention provides a series of schizophrenia-related pathogenic genes

Method used

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Embodiment Construction

[0022] As shown in sequence 1-1280 in the sequence listing, missense mutations, deletions or insertion mutations of exons in chromosomes closely related to schizophrenia are given.

[0023] Whole genome association study (WGAS): Whole genome linkage and association analysis uses a set of genetic markers covering the whole genome to detect the co-segregation of susceptibility genes in a family or population. It is an objective method. Not relying on any hypothesis, it is still one of the main methods for identification and identification of pathogenicity-related genes. In 2011, the Shandong Provincial Government adopted our suggestion and finally included the "Mental Disease Gene Mapping and Cloning Technology" in the "Twelfth Five-Year" Science and Technology Development Plan of Shandong Province; for polygenic diseases such as schizophrenia, Usually, genome scanning is performed first; the disease-related loci are located in a certain region of the chromosome, and then the ca...

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Abstract

The invention relates to the technical field of genes, and particularly relates to pathogenic genes of schizophrenia, which are as shown in sequences 1-1280 in sequence tables, gene-coded proteins in any sequence table of the sequence tables, and genes in any sequence table of the sequence tables as target positions for detecting probes or primers. Gene mutation leading to schizophrenia is determined through screening, the investigative basis and direction for further developing methods and medicines for treating schizophrenia are provided, and the pathogenic genes have epoch-making meaning in the history of research and treatment of human diseases.

Description

Technical field [0001] The invention involves the field of genetic technology, which specializes in the pathogenic genes of schizophrenia, and also involves the purpose of the pathogenic genes of schizophrenia. Background technique [0002] The cause of schizophrenia is related to heredity. It is characterized by inconsistency between thinking, emotion, and behavior. Its prevalence is about 1%, which seriously restricts social stability and development.Its clinical manifestations are mainly thinking, emotional, and behavioral disorders, and they are often accompanied by perceptual abnormalities.The prevalence of schizophrenia is generally about 0.55%, which is also related to the survey time and object (such as China 0.413%, 0.51%in the United States, 5.3%in a certain area in London, Palau 1.99%New Zealand 0.97%, Spain 0.30%, and 0.30%.Ireland is 0.39%), this difference may stem from the frequency time, region, and the differences between the frequency of the pathogenic genes, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C07K14/47C12Q1/68
Inventor 陈刚陈星
Owner 陈刚
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