Dispense interface for use with a drug delivery device for delivery of two or more drug agents

Abstract

A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body (1210) and an inner body (2000). The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle (4000) is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle (4050) is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold (2300) is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber. The dispense interface may further comprise a lockout device preventing dispense interface reuse.

Description

technical field [0001] This patent application relates to medical devices and methods for delivering at least two pharmaceutical agents from separate reservoirs using a device having a programmable dose setting mechanism and a single dispense interface. Such pharmaceutical agents may include first and second agents. A single dose setting procedure initiated by the user causes the drug delivery device to calculate a dose of the second drug agent based on the selected therapeutic dose algorithm. This single dose setting procedure initiated by the user may also cause the drug delivery device to calculate a dose of the third drug agent based on a (possibly) different selected therapeutic dose algorithm. Such an algorithm can be pre-selected prior to dose setting or selected when setting the dose. [0002] The pharmaceutical agent may be contained in two or more dosage reservoirs, containers or packages each containing separate (single drug composition) or premixed (mixed multipl...

AI Technical Summary

Problems solved by technology

Because of such potential problems, certain premix formulations including two or more active agents may not be suitable because these premix formulations will have fixed ratios of active ingredients that cannot be determined by a health care professional or user. Change

Additional problems arise where multi-drug combination therapy is required, as many users cannot cope with having to use more than one drug delivery system or necessitate precise calculation of the required dose combination

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