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Preparation method and application of Gegenqinlian tablet
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A technology of Gegen Qinlian and Scutellaria baicalensis, which is applied in the field of preparation of Gegen Qinlian tablets, can solve the problems of large dosage for patients, rough process, and many impurities, and achieve the effect of reducing the dosage
Inactive Publication Date: 2015-06-24
王玉璇
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[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Gegen Qinlian Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product
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Embodiment 1
[0016] Take 1000g of kudzu root, 375g of scutellaria baicalensis, 375g of coptis, and 250g of Zhigancao into a CO2 supercritical extractor. Ethanol is used as an entrainer. The entrainer accounts for 4% of the total extraction solvent by volume. The extraction pressure is 15MPa, the temperature is 30°C, and the CO2 flow rate is 1m1 / g crude drug·min, extraction time 150min, to obtain supercritical extract, add starch, 70% ethanol to make granules, dry, compress into tablets, and make 500 tablets, each weighing 0.5g.
Embodiment 2
[0018] Take 1000g of Pueraria root, 375g of Scutellaria baicalensis, 375g of Coptis chinensis, and 250g of roasted licorice and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.
Embodiment 3
[0020] Take 1000g of Pueraria root, 375g of Scutellaria baicalensis, 375g of Coptis chinensis, and 250g of roasted licorice and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.
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Abstract
The invention provides a preparation method of a Gegenqinlian tablet. The Gegenqinlian tablet is prepared by crude drugs of 1,000 g of kudzuvine roots, 375 g of baikal skullcap roots, 375 g of coptis roots and 250 g of honey-fried licorice roots through supercritical extraction, so that the content is improved greatly, and the dose is reduced. The invention further provides an application of the Gegenqinlian tablet in preparing drugs for inhibiting cell proliferation of leukemia cells K562.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Gegen Qinlian tablets. Background technique [0002] Pueraria qinlian tablets are recorded in 1000g of Pueraria lobata, 375g of Scutellaria baicalensis, 375g of Coptis chinensis, and 250g of roasted licorice. For the above four flavors, take 225g of Pueraria lobata root and grind it into fine powder. liquid, filtered, and the filtrate was properly concentrated; the percolation method (Appendix IO) under the items of Scutellaria baicalensis and Coptidis rhizome extracts and extracts (Appendix IO), respectively used 50% ethanol as solvent, soaked for 24 hours and then percolated, collected the filtrate, and recovered After that, ethanol is combined with the above-mentioned concentrated solution, concentrated into a thick paste, added with kudzu root powder, mixed evenly, dried, made into granules, dried, pres...
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