Suppository for curing gynecological diseases and preparation method thereof

A technology for gynecological diseases and suppositories, which is applied in the field of medicine and its preparation, can solve the problems of large polarity difference between the main medicine and the matrix, large invagination at the bottom of the suppository, short duration of drug effect, etc., and achieve good drug dispersion and physical and chemical stability Good performance, good appearance, and simplified prescription process

Active Publication Date: 2014-01-01
SHENZHEN OASIS PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current commercially available Baofukang suppository still has the following technical problems: 1. The stability is poor, and it is easily deformed when the temperature exceeds 20 degrees Celsius, and it is not easy to store, the storage time is short, and it is inconvenient for patients to use; 2. The effective time is longer, and it takes more than 30 minutes to melt, which affects the effect of the drug; 3. The duration of the drug effect is short. Due to the limitation of raw materials, the effect of the drug needs to be further improved, which prolongs the treatment time
However, in the existing commercially available Baofukang suppository test, it was found that the bottom of the suppository had a large invagination, and it was prone to delamination. The applicant found that the reason was that the polarity of the main ingredient and the matrix was quite different; In the environment, it is easy to absorb moisture and deform

Method used

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  • Suppository for curing gynecological diseases and preparation method thereof
  • Suppository for curing gynecological diseases and preparation method thereof
  • Suppository for curing gynecological diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A suppository for treating gynecological diseases, which is prepared by the following raw materials according to the stated weight: zedoary oil 82g, borneol 75g, stearin (model: Suppocire B type, Gattefosse) 1340g, laurocaprone 15.5g, 95% ethanol 77.5g.

[0021] A preparation method of a suppository for treating gynecological diseases. Take turmeric oil and borneol, mix evenly, add it to 77.5g of ethanol, stir to dissolve, and prepare a medicinal liquid for later use; another 1340g of stearin is heated at 50-70°C to make it hard. Melt the fat, stop heating when it melts to 3 / 4, use residual heat to melt the matrix completely, add 15.5g of laurocaprazine, stir well, add the above prepared liquid medicine, continue stirring, cool to a suitable temperature, pour Put it into a suppository mold, take it out after cooling, and make 1000 capsules.

Embodiment 2

[0023] A suppository for treating gynecological diseases, which is prepared by the following raw materials according to the stated weight: Zedoary Oil 82g, Borneolum 75g, stearin (Model: Suppocire BS 2 X, Gattefosse) 1350 g, laurocaprolactone 23.25 g, 95% ethanol 77.5 g.

[0024] A preparation method of a suppository for treating gynecological diseases. Take turmeric oil and borneol, mix evenly, add it to 77.5g of ethanol, stir to dissolve, and prepare a medicinal liquid for later use; another 1350g of stearin is heated at 50-70°C to make it hard. Melt the fat, stop heating when it melts to 3 / 4, use residual heat to melt the matrix completely, add 15.5g of laurocaprazine, stir well, add the above prepared liquid medicine, continue stirring, cool to a suitable temperature, pour Put it into a suppository mold, take it out after cooling, and make 1000 capsules.

Embodiment 3

[0026] A suppository for treating gynecological diseases, which is prepared by the following raw materials according to the stated weight: Zedoary Oil 82g, Borneolum 75g, stearin (Model: Suppocire BS 2 X, Gattefosse) 1360 g, laurocaprazine 31 g, 95% ethanol 77.5 g.

[0027] A preparation method of a suppository for treating gynecological diseases. Take turmeric oil and borneol, mix evenly, add it to 77.5g ethanol, stir to dissolve, and prepare a medicinal liquid for later use; additionally take 1360g stearin, heat at 50-70°C to harden Melt the fat, stop heating when it melts to 3 / 4, use residual heat to melt the matrix completely, add 15.5g of laurocaprazine, stir well, add the above prepared liquid medicine, continue stirring, cool to a suitable temperature, pour Put it into a suppository mold, take it out after cooling, and make 1000 capsules.

[0028] The present invention will be further described below in conjunction with test data.

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PUM

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Abstract

The invention discloses a drug and a preparation method thereof, and especially relates to a suppository for curing gynecological diseases and a preparation method thereof. The suppository for curing gynecological diseases is composed of following raw materials in parts by weight: 82 parts of zedoary turmeric oil, 75 parts of borneol, 1340 to 1360 parts of tristearin, 15.5 parts of laurocapram, and 77.5 parts of 95% ethanol. The preparation method preferably picks a fat-soluble substrate as the suppository substrate to prepare a suppository for curing gynecological diseases, and the suppository has the characteristics of small irritation, good stability, easy storage, difficulty in deforming because of damp absorption, convenience in transportation and using, short onset time, and long lasting curative effect.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a suppository for treating gynecological diseases and a preparation method thereof. Background technique [0002] Diseases of the female reproductive system are gynecological diseases, including vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, ovarian diseases, etc. Gynecological diseases are common and frequently-occurring diseases of women. However, because many people lack proper understanding of gynecological diseases, lack of health care for the body, and various bad living habits, the physical health is deteriorating, causing some women to suffer from diseases that cannot be cured for a long time, which brings great harm to normal life and work. Big inconvenience. Abnormal leucorrhea and vaginitis in gynecological diseases are common and frequently-occurring diseases in gynecological diseases. Bring great inconvenience to female ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/02A61K47/14A61P15/00A61P15/02A61K31/045
Inventor 于翔
Owner SHENZHEN OASIS PHARMA
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