Aseptic cartridge and dispenser arrangement

Abstract

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

Description

technical field [0001] The present invention relates generally, preferably, but not exclusively, to disposable cartridges for use with drug delivery devices, and more particularly to sterile mixing cartridges for drug delivery devices. Background technique [0002] Drugs, especially injectable drugs, need to be stored sterile in aseptic commercial packaging until the time of use. Some medications are stored in prefilled single dose dispensing devices, such as prefilled syringes, eg from Vetter (Ravensburg, Germany). However, most injectable drugs are stored in sterile packaging and delivered to a dispensing device (ie, drug delivery device) shortly before use. The term dispensing device includes, but is not limited to, hypodermic syringes, microneedle syringes, micropumps, auto-injectors, jet injectors, topical dispensers, intradermal delivery devices, patch pumps, ear dispensers, oral dispensers, Eye droppers, automatic injectors, infusion sets, or any other type of drug ...

AI Technical Summary

Problems solved by technology

[0004] However, the prior art suffers from several disadvantages: (a) for many injectable drugs such as vaccines, these packages are often expensive and economically impractical; (b) where mixing of the components of the drug is required, while the process is complex and error-prone; and (c) the delivery of the drug or its components from one container to another or to a dispensing device is accomplished in a non-sterile field and is prone to errors. risk of contamination

In addition, the increase in assembly and disassembly steps increases the risk of handling errors and contamination of deliverable formulations

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