Preparation method of veterinary long-acting preparation of imidocarb dipropionate

Abstract

The invention relates to a preparation method of a veterinary long-acting preparation of imidocarb dipropionate. The preparation method comprises the following steps: (1) dissolving imidocarb dipropionate into water for injection to obtain an internal water phase; (2) dissolving a polylactic acid-glycolic acid copolymer into an organic solvent to obtain an organic phase; (3) adding the internal water phase into the organic phase, and emulsifying to obtain primary emulsion; (4) adding the primary emulsion into a sodium chloride solution of polyvinyl alcohol, and emulsifying to obtain multiple emulsion; (5) adding the multiple emulsion into a sodium chloride solution, removing impurities, and drying, thereby obtaining the long-acting preparation. The veterinary long-acting preparation of imidocarb dipropionate is prepared from poly(DL-lactic acid-glycolic acid) copolymer with the specific mole ratio of monomer polylactic acid and glycolic acid as an auxiliary material and imidocarb dipropionate microspheres prepared by the secondary emulsification method. By adopting the preparation, the defects that an existing medicament for treating bovine babesiosis is short in time of duration, is required to be fed repeatedly, and cannot maintain the prevention effect for a long time are solved.

Description

technical field [0001] The invention relates to a preparation method of a long-acting imidazolium dipropionate veterinary preparation, in particular to a preparation method of a long-acting imidazuron dipropionate preparation for bovine babesiosis, belonging to the technical field of preparation of veterinary drugs . Background technique [0002] Bovine babesiosis (formerly known as bovine pyrosomiasis) is a parasitic disease caused by protozoa of the genus Babesia parasitic on the blood cells and reticuloendothelial system of cattle. It is a hematological protozoan disease transmitted by ticks. Acute, high morbidity and mortality, is one of the most serious parasitic diseases recognized by countries in the world to endanger the cattle industry. The disease is prevalent in many regions of my country, causing large economic losses. Under the situation that there is no safe and effective vaccine available for large-scale application at present, it is particularly important t...

AI Technical Summary

Problems solved by technology

[0006] However, there is no bibliographical report on the preparation of long-acting preparations by imidazuron dipropionate by double emulsion method at present.

Images