Camostat mesilate orally disintegrating tablet, and preparation method and new application thereof

A technology of camostat mesylate and orally disintegrating tablets, which is applied in the field of camostat mesylate orally disintegrating tablets and its preparation, and can solve problems such as difficulty in swallowing tablets, burning pain in the digestive tract, and high incidence of stomatitis , to achieve the effects of good promotion prospects, easy swallowing, and simple and easy preparation process
CN103585125BActive Publication Date: 2015-04-08BEIJING TIDE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING TIDE PHARMA
Publication Date
2015-04-08

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Abstract

The invention discloses an orally disintegrating camostat mesylate tablet, a preparation method thereof and a new application thereof. The orally disintegrating tablet contains 10% to 30% of the main drug camostat mesylate, 40% to 70% of a filler, 0% to 20% of a binder, and 2% to 10% of a disintegrant in parts by weight. %, flavoring agent 2%-8%, glidant 0%-5%, lubricant 0.5%-2.5%; the preparation can be prepared by wet granulation or powder direct compression. The present invention provides an orally disintegrating tablet of camostat mesylate, which is convenient to take, has a good taste, and has a rapid effect on indications. Improve the patient's medication compliance. Meanwhile, the product prepared by the present invention can be used for the existing indications such as acute exacerbation of chronic pancreatitis and postoperative reflux esophagitis. Research has found that it also has anti-inflammatory effects on oral mucositis caused by chemotherapy. New therapeutic uses.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an orally disintegrating camostat mesylate tablet, a preparation method thereof and a new application thereof. Background technique

[0002] Camostat mesilate (Camostat Mesilate) chemical name is dimethylcarbamoylmethyl 4-(4-guanidinobenzyloxy) phenylacetic acid mesylate, which is a synthetic non-peptide protease inhibitor. It can relieve the acute attack of chronic pancreatitis and improve the symptoms of postoperative reflux esophagitis. After oral administration, this product quickly acts on the body's kinin system, fibrinolytic system, coagulation system and complement system, immediately blocks the activity of related enzymes and inhibits their abnormal hyperactivity, thereby relieving the symptoms and pain of chronic pancreatitis and improving amylase. value. In addition, it can improve postoperative reflux esophagitis by inhibiting trypsin in the re...

Claims

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