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Application of Artoxanthochromane in helicobacter pyloridis-resistant drug

A technology of anti-helicobacter pylori and drugs, applied in the field of application of Artoxanthochromane in anti-helicobacter pylori drugs, can solve the problems of destruction of bacterial flora in the digestive tract, indigestion, etc., and achieve the effect of highlighting substantive characteristics and strong inhibitory activity

Inactive Publication Date: 2014-02-26
常州科立信医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora

Method used

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  • Application of Artoxanthochromane in helicobacter pyloridis-resistant drug
  • Application of Artoxanthochromane in helicobacter pyloridis-resistant drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Artoxanthochromane tablet involved in the present invention:

[0013] Take 5 grams of compound Artoxanthochromane, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Artoxanthochromane capsule involved in the present invention:

[0015] Get 5 grams of the compound Artoxanthochromane, add 195 grams of starch, mix evenly, and make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1: Pharmacological experiment of Artoxanthochromane

[0018] 1) Tested strains

[0019] Helicobacter pylori standard strain ATCC43504 was purchased from American Type Culture Collection (ATCC). 15 clinical strains of Hp were collected from patients who received gastroscopic examination in Department of Gastroenterology, Jiangsu Provincial People's Hospital, Laboratory Department of Jiangsu Provincial Hospital of Traditional Chinese Medicine, and Gastroscopy Department of Nanjing Children's Hospital; For patients with verrucous gastritis, firstly, they were confirmed as Hp-positive by rapid urease test, and then 1-2 pieces of gastric antrum mucosa were taken, minced and inoculated with 8% horse serum, trimethoprim 1.25g / L, multi- Colistin B2500U / L, vancomycin 10mg / L Columbia selective agar medium, cultured at 37°C in a micro-aerobic environment (5% O2, 10% CO2 and 85% N2) for 72 hours. Bacteria were collected, oxidase, catalase and urease were iden...

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Abstract

The invention discloses application of Artoxanthochromane in preparation of a helicobacter pyloridis-resistant drug. Artoxanthochromane can be used for treating acute gastritis, chronic gastritis, gastric ulcer, duodenum ulcer and other diseases and is applied to the preparation of drugs for treating acute gastritis, chronic gastritis, gastric ulcer and duodenum ulcer. Artoxanthochromane has a brand new type of skeleton, has high inhibitory activity for helicobacter pylori as well as outstanding substantial characteristics, and also shows a remarkable progress on prevention and treatment of helicobacter pyloridis infection.

Description

technical field [0001] The present invention relates to the new application of the compound Artoxanthochromane, in particular to the application of Artoxanthochromane in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of proton pump inhibitor (PPI) plus two antibiotics (choose two from clarithromycin, amoxicillin, tetracycline, metronidazole, etc.). The most important factor affecting triple therapy is considered to be the resistance of Hp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P31/04A61P1/04
Inventor 陈军
Owner 常州科立信医疗器械有限公司
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