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A kind of targeted positioning type film coating premix and preparation method thereof

A film coating and positioning technology, which is applied in the direction of pill delivery, sugar-coated pills, inorganic non-active ingredients, etc., can solve the problems of low moisture resistance and crack resistance, complicated operation methods, and high precision requirements, and achieve improved moisture resistance. , reduce adverse reactions, and ensure stability

Inactive Publication Date: 2016-05-11
BEIJING YINGMAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem that the above-mentioned common film coating cannot change the location and speed of drug release by adjusting the ratio of ingredients, and control the location and speed of various drug releases by changing the thickness of the film, the pore size and curvature of the film structure. Due to the technical problems of complex operation methods, high precision requirements, and low moisture resistance and crack resistance, the present invention discloses a film coating pre-treatment method that can meet the requirements of various drugs for specific release sites and speeds only by changing the amount of ingredients. Mixing agent, also discloses the preparation method of this film coating premixing agent simultaneously, and, product among the present invention compares with the product in the prior art, has higher moisture-proof, anti-crack performance

Method used

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  • A kind of targeted positioning type film coating premix and preparation method thereof
  • A kind of targeted positioning type film coating premix and preparation method thereof
  • A kind of targeted positioning type film coating premix and preparation method thereof

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Embodiment 1

[0038]

[0039]

Embodiment 2

[0041]

[0042]

Embodiment 3

[0044]

[0045] Above-mentioned embodiment 1-3 all adopts following method to prepare

[0046](1) Weigh the specified amount of solid coating material in turn, pour it into a mixer with a stirring paddle, start the paddle of the mixer, mix and stir at room temperature for 1 hour, then gradually add depurified water slowly, and then mix and stir for 30 minutes. Then slowly add other liquid coating materials into the mixer, mix and stir for 1 hour, wherein the rotating speed of the stirring blade is 2700 rpm;

[0047] (2) After drying the mixture in the previous step for 5 hours at 35-45°C, take a sample for inspection, and if the moisture content is ≤8%, if the product is qualified, proceed to the next step. If the moisture content is >8%, continue to dry;

[0048] (3) Grind the dried mixture in step (2), grind for 7 hours, pass through a 200-mesh sieve, and mix for 60 minutes to obtain the finished targeted film coating premix.

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Abstract

The invention discloses a targeted positioning film coating premixed agent, and a preparation method thereof. Raw material ratio of a film forming material, a plasticizer and a dispersant is disclosed. The preparation method comprises following steps: according to the raw material weight ratio, the film forming material, the ingredients above and the balance purified water are mixed and stirred at normal temperature for 1h; the mixture is dried for 5h, samples are taken for examination, and a following process is performed if the mixture is qualified; and the dried mixture is grinded for 5h, and is mixed for 60min to be uniform so as to obtain the targeted positioning film coating premixed agent. According to the preparation method, composition proportion of the ingredients can be adjusted according to demands on tablet cores, so that drug release is performed when the tablet cores reach to demanded preset positions; the preparation method is simple, and the targeted positioning film coating premixed agent is prepared via physical treatment processes, so that material properties are not changed, the targeted positioning film coating premixed agent is safe for application, performance is reliable and stable, cost is low, and the targeted positioning film coating premixed agent can be popularized and applied as a medicinal preparation targeted positioning coating material.

Description

technical field [0001] The invention belongs to the technical field of drug coating, and in particular relates to a targeted positioning type film coating premix and a preparation method thereof. Background technique [0002] In the contemporary society with the rapid development of medical technology, people have higher and higher requirements for pharmaceutical preparation technology, which is specifically reflected in the safety, effectiveness, and quality stability of drugs. Pharmaceutical preparation manufacturers can improve the level of early research and development, Select raw and auxiliary materials for production, strictly control the production process, design and use suitable packaging materials and other means to meet the requirements for drug safety and stability. However, in some cases where local localization of the drug is required to exert its curative effect, it is impossible to achieve the purpose of drug localization and exert its curative effect only b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/14A61K47/02A61K9/28
Inventor 陈佩英胡崇茂
Owner BEIJING YINGMAO PHARMA
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