Application of schisandra monomer compound in the preparation of drugs for the prevention and treatment of hepatotoxicity caused by paracetamol

Abstract

The invention discloses the application of a schisandra monomer compound in the preparation of drugs for preventing and treating liver toxicity caused by APAP. The schisandra monomer compound is schisandrin A, schisandrin C, schisandrin alcohol A or schisandrin ester A. It was found through experiments that the Schisandra-related monomer compounds can significantly reduce the contents of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in APAP-induced liver injury model animals, and inhibit the reduction of glucocorticoids in liver cells. The depletion of glutathione, and effectively improve the degree of liver cell necrosis, the experimental results show that Schizandra monomer compounds have significant therapeutic and protective effects on the symptoms of liver toxicity caused by APAP.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Schisandra chinensis monomer compounds in the preparation of drugs for preventing and treating hepatotoxicity caused by paracetamol. Background technique [0002] Schisandra chinensis is the mature fruit of the perennial deciduous vine of Magnoliaceae, which is divided into northern Schisandrachinensis (Turcz.)baill and southern SchisandrasphenantheraRehd.etWils. Schisandra chinensis is rich in lignans, triterpenes, sesquiterpenes, organic acids, volatile oils and polysaccharides, etc. Among them, lignans are beneficial to the human body in many ways, and their application scope and development prospects are getting more and more popular focus on. As a traditional Chinese medicine, Schisandra has the functions of nourishing qi and promoting body fluid, astringing the lungs and nourishing the kidneys, relieving diarrhea, astringent essence, and calming the n...

AI Technical Summary

Problems solved by technology

[0004] N-acetylcysteine ​​(NAC) is currently a classic drug used clinically for the treatment of acute APAP poisoning, but the limitation of this drug is that its therapeutic window is narrow, and it is ineffective for the treatment of the acute late stage of APAP poisoning, and long-term administration High-dose NAC can interfere with mitochondrial metabolism in normal hepatocytes, block NF-kB signaling pathway and inhibit liver regeneration after APAP liver injury

Images