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Medical antibacterial wound dressing and preparation method thereof

A wound dressing and raw material technology, applied in the field of medical materials, can solve problems such as poor absorption of wound exudate, secondary trauma of bleeding, iatrogenic pollution, etc., and achieve significant economic and social benefits, good compatibility, No allergic reaction effect

Active Publication Date: 2015-06-24
北京百利康生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are many problems in the practical application of medical dressings. For example, dressings absorb wound exudate and adhere to the wound surface. When changing dressings, new epithelial and granulation tissue are often destroyed, causing bleeding and causing secondary trauma; some dressings have poor air permeability, Non-degradable (such as: polyacrylonitrile, etc.), causing iatrogenic pollution; some dressings do not absorb wound exudate well, and are easy to breed bacteria

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Choose the middle viscosity chitosan that viscosity value is 0.25Pa s, chitosan is dissolved in 75wt% acetic acid solution, is configured into the chitosan liquid that weight percentage is 15wt%, chooses 45 kilograms of chitosan liquids, hyaluronic acid 5 kg of acid, 15 kg of gelatin, and 7 kg of sodium carboxymethyl cellulose; react at 220°C for 1.5 hours, cool down and defoam to obtain a uniform film, freeze-dry and aseptically package, which is the finished product. The semi-permeable TPU waterproof backing holds in place while in use.

Embodiment 2

[0028] Choose the middle viscosity chitosan that viscosity value is 0.65Pa s, chitosan is dissolved in 70wt% acetic acid solution, is configured into the chitosan liquid that weight percent is 10wt%, chooses 45 kilograms of chitosan liquids, hyaluronic acid 5 kg of acid, 15 kg of gelatin, 7 kg of sodium carboxymethyl cellulose, and 10 kg of polyethylene glycol (PEG400); react at 220°C for 1.5 hours, cool down and defoam to obtain a uniform film, freeze-dry and aseptically package , which is the finished product. The semi-permeable TPU waterproof backing holds in place while in use.

Embodiment 3

[0030] Choose the middle viscosity chitosan that viscosity value is 0.35Pa s, chitosan is dissolved in 65wt% acetic acid solution, is configured into the chitosan liquid that weight percent is 5wt%, chooses 45 kilograms of chitosan liquids, hyaluronic acid 5 kg of acid, 15 kg of gelatin, 7 kg of sodium carboxymethyl cellulose, and 15 kg of glycerin; react at 220°C for 1.5 hours, cool down and defoam to obtain a uniform film, freeze-dry and aseptically package, which is the finished product. The semi-permeable TPU waterproof backing holds in place while in use.

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Abstract

The invention discloses a medical antibacterial wound dressing which is prepared by copolymerizing the following raw materials in parts by weight: 10-55 parts of chitosan, 1-60 parts of hyaluronic acid, 5-10 parts of sodium carboxymethylcellulose, 1-35 parts of gelatin, 1-20 parts of polyethylene glycol, 1-30 parts of glycerin and 1-20 parts of polyoxyethane. When in use, the wound dressing is fixed by a semipermeable thermoplastic polyurethane elastomer (TPU) waterproof backing. The prepared wound dressing is simple in preparation process, diversified in shape, convenient, practical, good in moisture penetrability, moisture absorptivity and biocompatibility, low in replacement frequency and suitable for wound protection of burn injury, scald injury and traumatic wounds.

Description

【Technical field】 [0001] The invention relates to the technical field of medical materials, in particular to a medical antibacterial wound dressing and a preparation method thereof. 【Background technique】 [0002] At present, there are many problems in the practical application of medical dressings. For example, dressings absorb wound exudate and adhere to the wound surface. When changing dressings, new epithelial and granulation tissue are often destroyed, causing bleeding and causing secondary trauma; some dressings have poor air permeability, Non-degradable (such as: polyacrylonitrile, etc.), causing iatrogenic pollution; some dressings do not absorb wound exudate well, and are easy to breed bacteria. Therefore, there is a need for a new type of medical dressing, which can maintain good air permeability and have a large liquid absorption capacity, and has antibacterial and wound healing effects. [0003] Chitosan is the only natural cationic active polysaccharide in natu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 施虹
Owner 北京百利康生化有限公司
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