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A kind of medicinal composite polymer material aqueous dispersion and application

A technology of composite polymer and dispersion liquid, which is applied in the field of medicine to achieve the effect of improving the problem of sticking to the wall, obvious slow release effect and easy industrial production.

Active Publication Date: 2016-12-07
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a kind of composite polymer material aqueous dispersion suitable for spray drying process to prepare slow-release fine granules, and to apply it in the spray drying process, and to improve the occurrence of common single polyacrylic resin aqueous dispersion spray drying. Adhesive wall problem, improve drug product yield

Method used

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  • A kind of medicinal composite polymer material aqueous dispersion and application
  • A kind of medicinal composite polymer material aqueous dispersion and application
  • A kind of medicinal composite polymer material aqueous dispersion and application

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Place 3 parts by weight of ethyl cellulose and 27 parts by weight of Eudragit RS in 50 parts by weight of absolute ethanol, stir magnetically, dissolve, add 70 parts by weight of distilled water, stir evenly, and volatilize to remove the ethanol in the mixed solution to obtain A homogeneous aqueous dispersion of composite polymers with a solids content of 30%.

[0051] The water dispersion, dexketoprofen and other auxiliary materials are mixed and dispersed evenly according to the prescription ratio, and then spray-dried, and the final product yield is 64.51% on average.

Embodiment 2

[0053] Place 3 parts by weight of ethyl cellulose and 24 parts by weight of Eudragit RS in 50 parts by weight of absolute ethanol, stir magnetically, dissolve, add 63 parts by weight of distilled water, stir evenly, and volatilize to remove the ethanol in the mixed solution to obtain A homogeneous aqueous dispersion of composite polymers with a solids content of 30%.

[0054] The water dispersion, dexketoprofen and other auxiliary materials are mixed and dispersed evenly according to the prescription ratio, and then spray-dried, and the final product yield is 61.03% on average.

Embodiment 3

[0056] Place 3 parts by weight of ethyl cellulose and 21 parts by weight of Eudragit RS in 50 parts by weight of absolute ethanol, stir magnetically, dissolve, add 56 parts by weight of distilled water, stir evenly, and volatilize to remove the ethanol in the mixed solution to obtain A homogeneous aqueous dispersion of composite polymers with a solids content of 30%.

[0057] The water dispersion, dexketoprofen and other auxiliary materials are mixed and dispersed evenly according to the prescription ratio, and then spray-dried, and the average yield of the final product is 52.57%.

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Abstract

The invention discloses a novel medical composite polymer material aqueous dispersion for preparation of sustained-release fine grains in a spray drying process, so that the problem of wall sticking when a single common polyacrylic resin aqueous dispersion is adopted for spray drying can be solved, and the drug product yield can be increased. The composite polymer material aqueous dispersion is simple in composition, convenient and controllable to prepare and uniform in granularity distribution, and is suitable for preparing sustained-release fine grains by the spray drying method; the prepared sustained-release fine grains have the characteristics of remarkable sustained-release effect, stable product quality, safety and environmental-friendliness, and the like, and are easy for industrial production.

Description

technical field [0001] The invention relates to a novel medicinal composite polymer material aqueous dispersion, which is suitable for preparing slow-release drug fine granules in a spray drying process and belongs to the technical field of medicines. Background technique [0002] Pharmaceutical polyacrylic resins include methacrylic acid copolymers and methacrylate copolymers, used as gastric coatings, enteric coatings, sustained and controlled release coatings, protective isolation coatings, sustained release matrix materials and The skeleton adhesive material of the skin drug delivery preparation has a wide range of uses, and the slow-release pharmaceutical polyacrylic resins include Eudragit RS and Eudragit RL, and its aqueous dispersions are Eudragit RS30D and Eudragit RL30D. Eudragit RS30D is an aqueous dispersion of a copolymer of ethyl acrylate, methyl methacrylate and trimethylaminoethyl methacrylate chloride (1:2:0.1) with a solids content of 30%. The high molecul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/32
Inventor 栾立标沈亚光
Owner CHINA PHARM UNIV
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