Method for extracting galanthamine by using lycoris aurea

Abstract

The invention discloses a method for extracting galanthamine by using lycoris aurea. The inflorescence of the lycoris aurea is taken as a raw material for extracting a galanthamine drug. An optimal method for recovering, drying and storing the inflorescence crude drug of the lycoris aurea and an optimal extraction technology are explored. The quality standard of the inflorescence crude drug of the lycoris aurea is worked out. By adopting the technical scheme, the extinct wild resource and ecological environment can be effectively protected, the clinical medication safety can be ensured by continuous long-term benefits; the method is low in labor intensity, small in proportion of labor costs, and low in production cost; the condition that the content of galanthamine in the produced dry flower of the crude drug lycoris aurea is much higher than that of the requirements of the crude drug bulb for producing the galanthamine in a pharmaceutical factory in the past is ensured, the extracted economic benefits, social benefits and ecological benefits are much superior to those of the traditional method, achievement of industrial production is facilitated, and the problem of supply of the galanthamine crude drug is thoroughly solved.

Description

technical field [0001] The invention relates to a method for extracting galantamine by using Amaryllis chrysalis. Background technique [0002] Galantamine (Reminy1) is a phenanthridine alkaloid derived from Lycoris plants, chemical name: 11-methyl-3-methoxy-4α,5,9,10,11, 12-Hexahydro-6H-benzofuro[3α,2-ef]benzazepin-6-ol hydrobromide. It is a reversible cholinesterase inhibitor, which can pass through the blood-brain barrier, restore the hindered neuromuscular conduction, and improve the paralysis of various peripheral neuromuscular disorders. Galantamine can reversibly and specifically bind to the active site of acetylcholinesterase (AChE), thereby inhibiting the activity of the enzyme, leading to an increase in the amount of acetylcholine in the synaptic cleft, thereby improving the functional transmission of cholinergic nerves and improving The cholinergic in the brain of AD patients can improve the patient's cognitive ability and self-care ability. Galantamine has a c...

AI Technical Summary

Problems solved by technology

Due to long-term excavation, wild resources are on the verge of depletion; resulting in tight supply of medicinal raw materials for galantamine and safety of clinical medication

At the same time, the hills in the production area were also riddled with holes, resulting in the loss of water resources and serious environmental damage.

At the same time, traditionally, the raw material for extracting galantamine is to dig the underground bulbs of Amaryllis chrysanthemum, which is only a one-time profit. The labor intensity of digging the bulbs of medicinal materials is high, the proportion of labor costs is large, and the production cost is high.