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Application of anti-ST2/IL-1R4 antibody in preparing medicament for preventing and treating pruritus

A technology of antibodies and drugs, applied in the direction of antibodies, drug combinations, skin diseases, etc.

Active Publication Date: 2014-06-11
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, there is no literature report on ST2 and pruritus prevention and treatment, and there is no clinical report on the direct treatment of pruritus with anti-ST2 antibody

Method used

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  • Application of anti-ST2/IL-1R4 antibody in preparing medicament for preventing and treating pruritus
  • Application of anti-ST2/IL-1R4 antibody in preparing medicament for preventing and treating pruritus
  • Application of anti-ST2/IL-1R4 antibody in preparing medicament for preventing and treating pruritus

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1. Experimental animals:

[0032] A total of 48 SPF-grade male BALB / c mice were used in this experiment, aged 8 weeks, weighing 16-20 g (Shanghai Slack Experimental Animal Co., Ltd.). The feeding conditions are clean level, 5-6 birds / cage, free water supply. The experimental animals were divided into groups by completely random method.

[0033] 2. Preparation of pruritus model:

[0034] 1) Histamine-dependent itching model: Compound 48 / 80 (Sigma, C2313), dissolved in normal saline (100ug / 50ul), injected subcutaneously on the back of the neck, and the control group was injected with the same amount of normal saline at the same site.

[0035] 2) Histamine-independent pruritus model: Chloroquine (Chloroquine, Sigma, C6628), dissolved in normal saline (200ug / 50ul), injected subcutaneously on the back of the neck, and the control group was the same as above.

[0036] 3. Evaluation of pruritus behavior:

[0037] Immediately after modeling, time was counted to observe the ...

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Abstract

The invention relates to the field of pruritus preventing and treating medicaments, relates to novel use of an anti-ST2 / IR-1R4 antibody, specifically relates to an application of an anti-ST2 / IL-1R4 antibody in preparing a medicament for preventing and treating pruritus, and particularly relates to an application of the anti-ST2 / IL-1R4 antibody in preparing a medicament for treating histamine-dependent and non-histamine-dependent type pruritus. Experiments prove that the anti-ST2 / IL-1R4 antibody has a remarkable inhibiting effect on compound 48 / 80 and a chloroquine-caused pruritus mouse model, and the histamine-dependent and non-histamine-dependent type pruritus can be remarkably relieved by locally giving ST2 neutralizing antibodies. The anti-ST2 / IR-1R4 antibody disclosed by the invention can be applied as an active medicament ingredient, and can be used for further preparing the medicament for preventing and treating pruritus.

Description

[0001] technical field [0002] The invention relates to the field of drugs for preventing and treating itching, in particular to the application of anti-ST2 / IL-1 R4 antibody in the preparation of drugs for preventing and treating itching. [0003] Background technique [0004] Pruritus is a common unpleasant sensation often accompanied by scratching. It is the main symptom of many systemic diseases and skin diseases, which can seriously affect the physical and mental health of patients and reduce the quality of life. Acute pruritus is mostly caused by kidney and biliary diseases and side effects of drugs, while chronic and severe pruritus often occurs in skin diseases such as atopic dermatitis in addition to the above diseases. Pruritus can be directly caused by chemical mediators of the skin, or it can be caused by changes in physical factors (such as temperature), which in turn can cause reactions in peripheral nerve fibers or even the central nervous system. [0005] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P17/04
Inventor 米文丽史甜甜杨天王彦青
Owner FUDAN UNIV
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