Liquor containing indacaterol maleate and inhalation spray of liqour

A technology of acid indene and solution, applied in aerosol delivery, medical preparations containing active ingredients, respiratory diseases, etc., can solve problems such as poor stability

Inactive Publication Date: 2014-06-18
熊妲妮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor stability of indacaterol maleate in solution, it is often administered in the form of powder inhalation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] prescription composition

[0026] name

composition

indacaterol maleate

4mg

citric acid

3g

Sodium citrate

8g

Sodium chloride

4g

Add water to

2000ml

[0027] Preparation:

[0028] Take the prescribed amount of citric acid, sodium citrate, and sodium chloride and dissolve them in sterilized water for injection. After stirring to dissolve, add the prescribed amount of indacaterol maleate, stir to dissolve, add sterilized water for injection to the full amount, and use a vertical Filter with fused glass filter balls to get 1000 pieces. The pH value is 5.0.

Embodiment 2

[0030] prescription composition

[0031] name

composition

indacaterol maleate

30mg

sodium acetate

20g

Sodium chloride

4g

[0032] ascorbic acid

55mg

Add water to

2000ml

[0033] Preparation:

[0034] Take the prescription amount of sodium acetate, sodium chloride, and ascorbic acid and dissolve them in sterile water for injection. After stirring to dissolve, add the prescription amount of indacaterol maleate, stir to dissolve, and adjust the pH value to 4.0 with 3mol / L acetic acid solution. Add water to the full amount, and filter with a vertically fused glass filter ball to obtain 1000 pieces.

Embodiment 3

[0036] prescription composition

[0037] name

composition

indacaterol maleate

10mg

Disodium phosphate

4g

Dipotassium phosphate

15g

Sodium chloride

1g

Sodium formaldehyde sulfoxylate

45mg

EDTA-Calcium Disodium

100mg

Add water to

2000ml

[0038] Preparation:

[0039] Take the prescribed amount of disodium hydrogen phosphate, potassium dihydrogen phosphate, sodium chloride, sodium formaldehyde sulfoxylate, and ethylenediaminetetraacetic acid-calcium disodium and dissolve them in sterile water for injection. After stirring to dissolve, add the prescribed amount of Malay Acid indacaterol, stir to dissolve, add water to the full amount, and filter with a vertically fused glass filter ball to obtain 1000 pieces. The pH is 6.5.

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PUM

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Abstract

The invention relates to liquor containing indacaterol maleate. The content of the indacaterol maleate is 2.0 mug/ml-15 mug/ml; while being used, content can be released in the forms of mists by virtue of pressure of a manual pump, ultrasonic spraying, an air compressor, and the like, and can be used for lung inhalation administration. The invention specifically relates to inhalation spray containing the indacaterol maleate.

Description

field of invention [0001] The invention belongs to the field of medicines, and in particular relates to a solution containing indacaterol maleate. When used, the contents are released in the form of mist by means of manual pumps, ultrasonic sprays, air compressors, etc., and are used for lungs. Preparations for inhalation. Background of the invention [0002] Chronic obstructive pulmonary disease (COPD) is a serious lung disease that makes breathing difficult. Symptoms can include shortness of breath, chronic cough, and excessive phlegm. An exacerbation may last for several weeks and lead to a decline in lung insufficiency, an increased risk of death, and may be accompanied by severe anxiety. The etiology of COPD is not very clear, but experts at home and abroad believe that smoking is the most important factor causing COPD. According to the National Heart, Lung and Blood Institute report, smoking is the leading cause of COPD, and CCWD is the fourth leading cause of death...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/12A61K31/4704A61P11/00
Inventor 熊妲妮孙文娟夏美华黄永文梁林
Owner 熊妲妮
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