Palladium-carbon catalyst capable of being applied mechanically for meropenem synthesis

Abstract

The invention discloses a palladium-carbon catalyst capable of being applied mechanically for meropenem synthesis. The palladium-carbon catalyst capable of being applied mechanically for meropenem synthesis comprises an activated carbon carrier, palladium and transition metal nano particles loaded on the activated carbon carrier and amorphous alloy nano particles of palladium and transition metal. The preparation method of the catalyst comprises the following steps: firstly, preparing a sulfide solution, then immersing wood based carbon into the sulfide solution to stir, filtering, and drying so as to obtain the activated carbon carrier; secondly, preparing an activated component mixed solution; thirdly, pulping the activated carbon carrier by an alkali compound water solution, and stabilizing under a stirring condition so as to obtain activated carbon size; fourthly, adding the activated component mixed solution into the activated carbon size, and stirring so as to obtain the catalyst; fifthly, aging a catalyst precursor by adopting sodium borohydride for reduction treatment, filtering and washing so as to obtain a finished product catalyst. The catalyst provided by the invention has the advantages of moderate activity and high selectivity; the catalyst can be applied mechanically, and thus the production cost of the catalyst for meropenem synthesis is reduced substantially.

Description

technical field [0001] The invention belongs to the technical field of catalyst preparation, and in particular relates to a palladium-carbon catalyst for synthesizing meropenem which can be applied mechanically. Background technique [0002] Carbapenem antibiotics mainly include meropenem, imipenem, panipenem, biapenem, ertapenem, faropenem, doripenem, etc. Among them, meropenem has the largest market demand and the most widely used widely. In the last step of its chemical synthesis, it is necessary to use palladium carbon catalyst for hydrogenolysis reaction, as shown in the following reaction formula, while removing the protecting groups PNB (p-nitrobenzyl) and PNZ (p-nitrobenzyloxycarbonyl) ), the palladium-carbon specification used to produce this product on the market is generally 5% to 7% palladium-carbon, and the catalyst charging amount is generally about 20% of the substrate quality, and the product yield is about 48%. The amount of palladium carbon catalyst used ...

AI Technical Summary

Problems solved by technology

The characteristic of this catalyst preparation process is to use the weak reducibility of stannous to prepare metal palladium colloids in a certain particle size range, and then load them on activated carbon. Industrial production has caused some inconvenience

[0006] With the repeated reduction of the sales price of meropenem, great pressure has been placed on the production cost of the drug. The existing palladium-carbon catalyst for the synthesis of meropenem has a high dosage, and the catalyst cannot be applied mechanically due to the presence of sulfur poisoning in the reaction precursor. Therefore, there is an urgent need to develop a palladium-carbon catalyst for meropenem that can be applied in order to alleviate the increasing cost pressure

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