Compound propelling system for Dermlin skin dressing

A skin and system technology, applied in the fields of chemicals, applications, and medical science for biological control, can solve the problems of non-explosive, non-sterilizing ingredients, and destruction of the ozone layer, so as to reduce the cooling effect and prevent frostbite on the skin surface , Expand the effect of applicable conditions

Inactive Publication Date: 2014-07-16
JIANGSU YENSSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the raw materials used as propellants in these products, freon is non-toxic, non-allergic and irritating; non-explosive, colorless, odorless, tasteless, does not chemically react with drugs, etc., and does not affect the stability of drugs. In the past, it was widely used in many aerosol products in this industry, but because it will destroy the ozone layer, it needs to be completely phased out according to the signed "Montreal Protocol on Substances that Deplete the Ozone Layer"
A safe and efficient aerosol composite projectile system that does not contain Freon, has good safety and fast volatilization has been invented. The patent number is ZL 200710020434.8. However, this projectile system does not contain disinfection and sterilization ingredients and is not suitable for Aerosol for medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Liquid nitrogen was used as the propellant, isopentane was selected as the dispersant or compatibilizer, and bromogeramine was used as a sterilizing agent. The ratio was 2 kg of liquid nitrogen, 7 kg of isopentane, 1 kg of bromogeramine, and 0.1 kg of Tween 80.

[0020] Isopentane and bromogeramine have suitable boiling points and are liquid at room temperature. Conventional production operations such as batching, stirring, and sub-packaging are very easy to control, and there is no need for equipment modification and major process condition changes during the production process.

[0021] Based on the above theoretical conditions, we conducted a series of experiments to verify:

[0022] 1) Solubility test of isopentane, bromogeramine, propellant liquid nitrogen, and Tween 80:

[0023] Test method: Mix isopentane, bromogeramine, liquid nitrogen and Tween 80 in a sealed thick glass bottle according to 7:1:2:0.1 (weight ratio), shake for 1 minute and let stand to observe w...

Embodiment 2

[0037] The propellant is liquid nitrogen, the dispersant or compatibilizer is cyclopentane, the sterilization and disinfectant is bromogeramine, the emulsifier is Tween 80, and the ratio is liquid nitrogen 2kg, cyclopentane 7kg, bromogeramine 1kg, Tween 80 is 0.1 kg. In the filling, the skin dressing Demoline powder produced by Jiangsu Yangsheng Bioengineering Co., Ltd. is used as the active ingredient, and the weight is 1kg. All the other are basically the same as Example 1.

Embodiment 3

[0039] The propellant is liquid carbon dioxide, the dispersant or compatibilizer is isopentane, the sterilization and disinfectant is bromogeramine, and the emulsifier is Tween 80. The ratio is 2kg of liquid carbon dioxide, 7kg of isopentane, 1kg of bromogeramine, and 0.1 kg of Tween 80. In the filling, the skin dressing Demoline powder produced by Jiangsu Yangsheng Bioengineering Co., Ltd. is used as the active ingredient, and the weight is 1kg. All the other are basically the same as Example 1.

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PUM

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Abstract

The invention relates to a compound propelling system for a Dermlin skin dressing, belonging to the technical field of aerosols. The compound propelling system substantially consists of a propellant and/or a cosolvent, a dispersant or a compatibilizer as well as a disinfectant and is characterized in that the propellant is liquid nitrogen or liquid carbon dioxide; the cosolvent, the dispersant or the compatibilizer is isopentane or cyclopentane; the disinfectant is bromogeramine, 2% glutaraldehyde disinfectant or 0.5% o-phthalaldehyde disinfectant; and the emulsifier is tween-80. The compound propelling system is wide in application range, good in safety and high in volatile speed, does not contain Freon, and can realize disinfection.

Description

technical field [0001] The invention relates to a composite propellant system in aerosol product components. It belongs to the field of aerosol technology. Background technique [0002] As an important class of industrial products, aerosols have been widely used in personal, household, industrial, agricultural, pharmaceutical, construction, animal husbandry, fire protection, security and many other fields. The aerosol consists of active ingredients and a composite propellant system. The composite propellant system is an important part besides the active ingredients, and generally consists of a propellant, a latent solvent, a dispersant or a compatibilizer. A certain ejection pressure is required to ensure the atomization effect, and it can be quickly vaporized without residue after spraying to avoid affecting the use effect of active ingredients. In the past, different aerosol products often used chlorofluorocarbons (Freon) or hydrocarbons, compressed gases, etc. as prope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/42A01N25/06A01N33/12A01N35/04A01N35/02A01P1/00
Inventor 周来生陶国新
Owner JIANGSU YENSSEN BIOTECH CO LTD
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