Method for determining chlorhexidine acetate content in sanitary towel

A technology of chlorhexidine acetate and determination method, which is applied in the field of determination of chlorhexidine acetate content in sanitary napkins, can solve the problem of blank detection of chlorhexidine acetate content, unfavorable product quality control and analysis, accuracy and reproducibility of results It can achieve excellent specificity, simple detection preparation, and strong method stability

Inactive Publication Date: 2014-07-23
云南白药清逸堂实业有限公司
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Problems solved by technology

[0011] Chlorhexidine acetate is popular in the field of disinfection and sanitation products for its high efficiency and wide application, but at present, the content detection of chlorhexidine acetate in products is more for liquid preparations containing chlorhexidine acetate, for non-liquid Preparations, that is, products that need to be effective through dissolution, especially the detection of chlorhexidine acetate content in polymer composite materials has alwa...

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  • Method for determining chlorhexidine acetate content in sanitary towel
  • Method for determining chlorhexidine acetate content in sanitary towel
  • Method for determining chlorhexidine acetate content in sanitary towel

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Embodiment Construction

[0044] The present invention will be further described below in conjunction with the examples. In this example, the sanitary napkin samples are taken from the "Ri Ri" brand sanitary napkins produced by Yunnan Baiyao Qingyitang Industrial Co., Ltd. In the present invention, after simple sample preparation of the sanitary napkin sample, after detection by an HPLC instrument, the external standard method is used to calculate and issue the test result, and the specific method is as follows.

[0045] Content determination:

[0046] Instruments: high performance liquid chromatography, Agilent1200; measuring flask, 50mL; acid burette, 50mL; ultrasonic cleaner, SK8200; Erlenmeyer flask with stopper, 250mL;

[0047] Reagents: ethanol, 50%; chlorhexidine acetate reference substance, Guizhou Dida Biological Co., Ltd., purity 98%; chromatographically pure acetonitrile; superior grade pure phosphoric acid; ultrapure water.

[0048] Steps:

[0049] A kind of assay method of chlorhexidine ...

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Abstract

The invention relates to a method for determining chlorhexidine acetate content in a sanitary towel. A dissoluble sample is prepared aiming at a water-insoluble paper sanitary towel product, detection is carried out under the fixed chromatographic condition at the wavelength of 260nm, and result calculation is carried out through an external standard method, so as to obtain chlorhexidine acetate content data in the sanitary towel. By adopting the method, the problem for detecting the chlorhexidine acetate content in the paper sanitary towel product is solved, the method is high in result accuracy, good in repeatability, good in stability, low in operative difficulty index, and applicable to a plurality of aspects such as production quality control, scientific research and the like, and the detection result can be quickly provided in batches.

Description

technical field [0001] The invention relates to a method for determining the content of chlorhexidine acetate, in particular to a method for determining the content of chlorhexidine acetate in sanitary napkins. Background technique [0002] Chlorhexidine Acetate (Chlorhexidine Acetate, abbreviated as CA), also known as chlorhexidine acetate, is a biguanide compound, and its pure product is white crystal. Chlorhexidine acetate is a disinfectant antiseptic, highly sensitive to Staphylococcus, Streptococcus mutans, Streptococcus salivarius, Candida albicans, Escherichia coli; moderately sensitive to Haemophilus Streptococcus; Proteus, Pseudomonas Genus, Klebsiella and Gram-negative bacteria are low susceptibility. The killing effect on Gram-positive bacteria and negative bacteria is stronger than that of bromogeramine and other disinfectants. Chlorhexidine acetate is widely used in disinfection and hygiene products because of its broad antibacterial spectrum, strong antibacte...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 张志全杨义寅
Owner 云南白药清逸堂实业有限公司
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