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Drug oral tablet for preventing and treating hyperlipidemia and preparation process thereof

An oral tablet and a technology for hyperlipidemia, which are applied in the field of oral tablet for preventing and treating hyperlipidemia and its preparation technology, can solve the problems of gastrointestinal tract damage, influence on application, unstable placement at room temperature and the like, and achieve simple and convenient production. The effect of taking

Active Publication Date: 2016-01-06
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, eugenol contains phenolic hydroxyl groups, which are volatile and irritating, and are unstable at room temperature, which affects its application.
In addition, long-term and large-scale use of aspirin can also damage the gastrointestinal tract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] aspirin eugenol 85g microcrystalline cellulose 50g Low-substituted hydroxypropyl cellulose 12.5g Sodium dodecyl sulfate 8.5g talcum powder 2.5g 2% hydroxypropyl methylcellulose 80ml production 480 tablets

Embodiment 2

[0015] aspirin eugenol 85g microcrystalline cellulose 45g Low-substituted hydroxypropyl cellulose 10g Sodium dodecyl sulfate 7.5g talcum powder 2.5g 2% hydroxypropyl methylcellulose 80ml production 480 tablets

Embodiment 3

[0017] aspirin eugenol 85g microcrystalline cellulose 43g Low-substituted hydroxypropyl cellulose 8.5g Sodium dodecyl sulfate 5.0g talcum powder 2.5g 2% hydroxypropyl methylcellulose 80ml production 480 tablets

[0018] Tablet preparation process is in the above-mentioned embodiment:

[0019] Aspirin eugenol raw material is ground into fine powder, passed through a 100-mesh sieve, mixed with microcrystalline fiber binder, 2 / 3 amount of sodium lauryl sulfate surfactant, 1 / 2 amount of lauryl sulfate Mix the sodium disintegrating agent evenly, add a 2% hydroxypropyl methylcellulose solution to make a soft material, and granulate with a 16-mesh standard sieve; dry the prepared granules in a drying oven at 50°C for 1 hour, After drying, the granules are passed through a 16-mesh sieve for granulation, and the prepared granules are mixed with the remaining 1 / 3 of the sodium lauryl sulfate surfactant, the remaining 1 / 2 of the sodium l...

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Abstract

The invention discloses an oral tablet of a drug for preventing and treating hyperlipidemia and a preparation process thereof. The oral tablet consists of 1 part by weight of aspirin eugenol ester as a raw material, 0.1-0.15 parts by weight of a disintegrant, 0.06-0.1 parts by weight of a surfactant, 0.5-0.6 parts by weight of a binder and 0.03 parts by weight of a lubricant. The auxiliary materials are compressed into tablets to make aspirin eugenol ester oral tablets, each weighing 0.265±0.005g. The preparation can be quickly disintegrated and dissolved, has the advantages of uniform dispersion, and its physical and chemical properties in all aspects meet the requirements of the 2010 edition of the Chinese Pharmacopoeia, and is convenient to take; pharmacological experiments show that the oral tablet can prevent and treat hyperlipidemia diseases.

Description

technical field [0001] The invention relates to an oral tablet of chemical drug aspirin eugenol ester and a preparation process thereof. The tablet can be rapidly disintegrated and dissolved, and can be used for preventing and treating hyperlipidemia. Background technique [0002] Inflammation is a common and frequently-occurring disease that threatens the health of humans and animals. Glucocorticoid steroid anti-inflammatory drugs can effectively control infectious inflammation and non-infectious inflammation, but long-term use can easily cause complications such as adrenal cortical function decline . Non-steroidal anti-inflammatory drugs are usually much less toxic and side effects than steroidal anti-inflammatory drugs, and aspirin is a representative of non-steroidal anti-inflammatory drugs with excellent anti-inflammatory and analgesic effects. In order to effectively control related inflammatory diseases, the development of new, efficient and safe non-steroidal anti-i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/621A61K47/38A61P3/06
Inventor 李剑勇刘希望杨亚军张继瑜周绪正李冰牛建荣魏小娟
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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