Benzoxazole derivative as well as preparation method and application thereof

A technology of benzoxazole and methyl benzoxazole is applied in the field of medicine to achieve the effects of preventing and treating hyperglycemia, promoting growth activity and enhancing metabolic growth
CN104016935AInactive Publication Date: 2014-09-03TIANJIN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV OF SCI & TECH
Publication Date
2014-09-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a benzoxazole derivative. The benzoxazole derivative is (5-methylbenzoxazole-2-phenyl)-3'-methoxybenzamide, can be applied to silent information regulator agonist SIRT1 and preparation of medicaments for reducing, improving, preventing and treating II-type diabetes mellitus or hyperglycemia, abnormal glucose tolerance, dyslipidemia and complications caused by those diseases due to the II-type diabetes mellitus. In-vitro saccharomycete experiments prove that the SIRT1 agonist, such as benzoxazole derivative (5-methylbenzoxazole-2-phenyl)-3'-methoxybenzamide can be used for promoting the growing activity of saccharomycetes, reinforcing metabolic growth, improving the activity of SOD (superoxide dismutase), Cu-Zn SOD and CAT (chloramphenicol acetyl transferase) in the body of drosophila melanogaster, reducing the content of MDA (methylene dioxyamphetamine), and increasing the expression quantity of anti-oxidation gene CAT mRNA (messenger ribonucleic acid).
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Description

technical field

[0001] The invention belongs to the technical field of medicine, in particular to a benzoxazole derivative and its preparation method and application. Background technique

[0002] Type Ⅱ diabetes accounts for 90% of total diabetes, and its main pathogenesis is insulin resistance, pancreatic β-cell failure and insulin secretion disorder. Patients with type Ⅱ diabetes are often accompanied by obesity, high blood pressure, high triglyceride or hypercholesterolemia. Hyperlipidemia is one of the main reasons for insulin resistance and islet β cell dysfunction. Commonly used hypoglycemic drugs include: insulin, sulfonylurea drugs, non-sulfonylurea insulin secretagogues, biguanide hypoglycemic drugs, insulin sensitizers, etc. Strong, damage to liver, kidney and other organs, some diabetics show obvious resistance to insulin. Therefore, finding new safe and effective anti-diabetic drugs by synthesizing new compounds and discovering new protein targets is an effect...

Claims

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