A kind of injection composition containing fosaprepitant dimeglumine and preparation method thereof

A technology of fosaprepitant dimeglumine and saprepitant dimeglumine, which is applied in the field of freeze-dried preparations of fosaprepitant dimeglumine for injection and its preparation, and can solve the problem of time-consuming freeze-drying process Energy and other issues, to achieve the effect of stable product quality, simple and controllable process, and energy saving
CN104042572BActive Publication Date: 2016-04-06JIANGSU AOSAIKANG PHARMA CO LTD
3 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU AOSAIKANG PHARMA CO LTD
Publication Date
2016-04-06

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a pharmaceutical composition containing fosaprepitant dimeglumine and a preparation method thereof. The pharmaceutical composition is composed of fosaprepitant dimeglumine, lactose, disodium edentate and tween-80, wherein a mass ratio among the fosaprepitant dimeglumine, the disodium edentate, the tween-80 and the lactose is 188-245.3:14.4-18.8:57.5-75:287.5-375. The composition is prepared in an aqueous containing alcohol in a freeze-drying manner. The preparation method is simple and controllable in processes and can reduce energy consumption. The pharmaceutical composition, prepared by the preparation method in the invention, is stable in quality and can ensure safety of clinical medication.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a freeze-dried preparation of fosaprepitant dimeglumine for injection and a preparation method thereof. Background technique

[0002] The chemical name of fosaprepitant dimeglumine is: [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethylphenyl)ethoxy] -3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-one-1H-1,2,4-triazol-1-yl]phosphate Di(N-methyl-D-glucosamine) salt, the chemical structure is shown in formula-I.

[0003]

[0004] Fosaprepitant dimeglumine for injection is a chemotherapeutic antiemetic drug, and it is suitable for the prevention and treatment of acute and severe complications caused by initial and repeated administration of moderate and large doses of emetic anticancer chemotherapy drugs (including high doses of cisplatin) when used in combination with other antiemetic drugs. and late nausea and vomiting. Fosaprepitant dimeglumine is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More