Dicranostigma leptopodum extract perfusate, and preparation method and application thereof

A technology for the extract of safflower grass, which is applied in the field of perfusion solution of sage grass extract, can solve the problems of endangering human health, increase of drug-resistant bacteria, drug residues, etc., and achieves the advantages of industrial production, no residue and side effects, Quality Controlled Effects

Inactive Publication Date: 2014-09-17
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If not treated in time, it can lead to suppuration, loss of lactation function and even death
The hazards are that mastitis leads to reduced milk production, abandoned dairy cows, sick cows and even death, plus medical expenses, which bring serious economic losses to farmers; at the same time, the pathogenic bacteria of clinical mastitis can also endanger human health through milk.
For a long time, my country's dairy farms have been treated with large doses of antibiotics and sulfonamides. While achieving good curative effect, it has also brought many new problems, such as the increase of drug-resistant bacteria and drug residues, which seriously affect the safety of dairy products.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method of the red grass extract perfusate of the present invention is as follows:

[0022] Add 1 kg of red grass and add water to decoct three times, add 6 kg of water each time, and decoct for 4 hours. After decocting, filter, combine the filtrates, concentrate to 1000 ml, and let cool; add 1000 ml of ethanol to refrigerate and precipitate at 4-5°C for four days, filter and discard the precipitate, and recover ethanol; add 2000 ml and 3000 ml of ethanol in sequence, both at 4-5 Refrigerate and precipitate at 5°C for two days, filter and discard the precipitate, recover ethanol, add sodium hydroxide to adjust the pH to 10, refrigerate at 4-5°C for 24 hours and filter, heat the filtrate in a water bath until it has no alcohol smell, add medicine to the liquid 15 ml of benzyl alcohol and 15 ml of Tween-80 as co-solvent, add water for injection to 1000 ml, adjust the pH to neutral 6-7, filter, pot, sterilize at 100°C for 30 minutes to obtain the extract pe...

Embodiment 2

[0024] The preparation method of the red grass extract perfusate of the present invention is as follows:

[0025] Add water to 1 kg of red grass and decoct three times, add 4 kg of water each time, and decoct for 2 hours. After decocting, filter, combine the filtrates, concentrate to 1000 ml, and let cool; add 1000 ml of ethanol to refrigerate and precipitate at 4-5°C for four days, filter and discard the precipitate, and recover ethanol; Refrigerate and precipitate at -5°C for two days, filter and discard the precipitate, recover ethanol, add sodium hydroxide to adjust the pH to 10, refrigerate at 4-5°C for 24 hours and filter, heat the filtrate in a water bath until it has no alcohol smell, add to the liquid medicine Add 15 ml of benzyl alcohol, 15 ml of Tween-80, add water for injection to 1000 ml, adjust the pH to 6-7, filter, pot, and sterilize at 100° C. for 30 minutes to obtain the perfusate of the extract of Herba chinensis. This product is a brown clear liquid, with ...

Embodiment 3

[0027] The preparation method of the red grass extract perfusate of the present invention is as follows:

[0028] Add 1 kg of red grass and add water to decoct three times, add 2 kg of water each time, and decoct for 1 hour. After decocting, filter, combine the filtrates, concentrate to 1000 ml, and let cool; add 1000 ml of ethanol to refrigerate and precipitate at 4-5°C for four days, filter and discard the precipitate, and recover ethanol; Refrigerate and precipitate at -5°C for two days, filter and discard the precipitate, recover ethanol, add sodium hydroxide to adjust the pH to 10, refrigerate at 4-5°C for 24 hours and filter, heat the filtrate in a water bath until it has no alcohol smell, add to the liquid medicine Add 15 ml of benzyl alcohol, 15 ml of Tween-80, add water for injection to 1000 ml, adjust the pH to 6-7, filter, pot, and sterilize at 100° C. for 30 minutes to obtain the perfusate of the extract of Herba chinensis. This product is a brown clear liquid, wi...

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PUM

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Abstract

The invention provides a preparation method of a Dicranostigma leptopodum extract perfusate. The method comprises the following steps: adding water to a Dicranostigma leptopodum extract, decocting, mixing filtrates, and concentrating to obtain a concentrate; and extracting with ethanol, removing ethanol, adding benzyl alcohol and Tween-80 to the above obtained ethanol removed medicinal liquid, adding injection water to a full dose, and sterilizing to obtain the Dicranostigma leptopodum extract perfusate. The invention also provides an application of the perfusate in the preparation of medicines for treating cow mastitis. The Dicranostigma leptopodum extract perfusate adopting the Dicranostigma leptopodum extract as an effective component has very good heat clearing, detoxifying, bacterium resisting, inflammation eliminating and virus resisting effects. The perfusate is a pure traditional Chinese medicinal preparation, contains no chemical components, and is in favor of the safety of dairy products. Products produced through extraction and preparation integrated production have the advantages of stable properties and controllable quality, and are in favor of industrial production. The perfusate has the advantages of definite effect, no residual or toxic side effects, and realization of use in the lactation period as an effective medicine for treating clinic mastitis of cows, and becomes a good substitute of antibiotics.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a perfusate of the extract of Herba chinensis. Background technique [0002] Hongmao grass is a plant of the genus Papaveraceae. It is widely distributed in the north and south of Qinling Mountains and Weishui River Basin in Gansu Province. Whether it is used as a whole herb or compounded, it has the effects of clearing away heat and detoxification, reducing swelling, relieving pain, and killing insects. In clinical use, it was found that the total effective rate of Hongmao grass on lymphatic tuberculosis, pulmonary tuberculosis, bone tuberculosis and sinus ulcers reached More than 90%, it has obvious therapeutic effects on various surgical sores, fistulas, intractable stomatitis, trauma, herpes zoster, fungal vaginitis, suppurative otitis media, aphthous ulcers and scabies. [0003] Clinical mastitis in dairy cows is an inflammation of the mammary glan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P15/14
Inventor 梁剑平陶蕾尚若锋赵凤舞王学红贾忠郝宝成刘宇郭文柱郭志廷
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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