Beautiful millettia root wall-broken preparation

A Niu Dali and preparation technology, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations of non-active ingredients, etc., can solve the problems of loss of active ingredients, easy moisture absorption, deterioration, etc., and achieve good disintegration And stability, simple granulation process, easy disintegration and dispersion

Active Publication Date: 2014-09-24
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using the traditional decoction method, on the one hand, it is easy to destroy the heat-sensitive components, and on the other hand, the decoction of the active ingredients is not complete, resulting in the loss of the active ingredients
The preparation of Niu Dali into Niu Dali superfine powder is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of powder specific surface area, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • Beautiful millettia root wall-broken preparation
  • Beautiful millettia root wall-broken preparation
  • Beautiful millettia root wall-broken preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take Niu Dalijing medicinal material, coarsely pulverize it into a coarse powder of about 100 mesh, and ultrafinely pulverize it into a powder with a particle size of 90% or less in the ultrafine powder, and add ethanol-water solution (the mass fraction of ethanol is 30%) Soft materials are produced by wet method, the ratio of solution to superfine powder is 0.4:1 (by weight), after mixing, a 10-mesh sieve is pre-installed, the extrusion speed is 50r / min, and the extrusion force is 1MPa to produce wet granules. The granules are placed in a hot air circulation oven, set the drying temperature at 85°C, and dried for 2.5 hours to dryness.

[0037]

[0038] Note: The full score is 10.

Embodiment 2

[0040] Take Niu Dalijing medicinal material, coarsely pulverize it into a coarse powder of about 100 mesh, and ultrafinely pulverize it into a powder with a particle size of 90% or less than 45 μm in the ultrafine powder, and add ethanol-water solution (the mass fraction of ethanol is 40%) Soft materials are made by wet method, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, a 10-mesh sieve is pre-installed, the extrusion speed is 70r / min, and the extrusion force is 0.7MPa to make wet granules. The wet granules were transferred to a vacuum microwave drying oven, the drying temperature was set at 45° C., and dried for 0.75 h until dry. After the granules were sized and sieved, the Niu Dali wall breaking preparation was obtained.

[0041]

[0042] Note: The full score is 10.

Embodiment 3

[0044] Take Niu Dalijing medicinal material, coarsely pulverize it into a coarse powder of about 100 mesh, and then superfinely pulverize it into a powder with a particle size of 90% or less of 45 μm in the ultrafine powder, and add ethanol-water solution (the mass fraction of ethanol is 60%) Soft materials are made by wet method, the ratio of solution to superfine powder is 0.8:1 (by weight), after mixing, pre-installed 20-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet granules. The wet granules were placed in a hot air circulation oven, set the drying temperature at 85°C, dried for 2.5 hours until dry, and the whole granules were sieved to obtain the Niu Dali wall breaking preparation.

[0045]

[0046] Note: The full score is 10.

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Abstract

The invention relates to a Chinese medicine preparation, and in particular relates to a beautiful millettia root wall-broken preparation. The beautiful millettia root wall-broken preparation is prepared as follows: crushing beautiful millettia root into wall-broken powder, then on the basis of quality control of an ethanol solution and the wall-broken powder, granulating by use of an ethanol-water wet method, extruding for forming at a certain rotating speed and drying, the method is high in granulation rate, and the prepared beautiful millettia root wall-broken preparation is high in bioavailability, strong in stability, and good in disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation for breaking the wall of Niu Dali. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. Howev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/486A61K47/10A61K9/16A61P21/00A61P29/00A61J3/00
Inventor 成金乐陈勇军梁学良钱锦花陈金梅
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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