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Application of dicliptera chinensis polysaccharide in preparation of medicines for treating liver injury caused by antituberculosis drugs

A dog liver vegetable and anti-tuberculosis technology, which is applied in the field of traditional Chinese medicine, can solve the problems that have not yet been reported on the protective effect of dog liver vegetable polysaccharides, and achieve good medicinal value, rich medicinal material resources, and good taste effects

Inactive Publication Date: 2014-10-08
GUILIN MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
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Problems solved by technology

Searching domestic and foreign studies on dog liver vegetable polysaccharides, there is no research report on the protective effect of dog liver vegetable polysaccharides on tuberculosis drug-induced liver injury

Method used

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  • Application of dicliptera chinensis polysaccharide in preparation of medicines for treating liver injury caused by antituberculosis drugs
  • Application of dicliptera chinensis polysaccharide in preparation of medicines for treating liver injury caused by antituberculosis drugs
  • Application of dicliptera chinensis polysaccharide in preparation of medicines for treating liver injury caused by antituberculosis drugs

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Embodiment Construction

[0016] The content of the present invention will be further described below in conjunction with the examples, but the present invention is not limited.

[0017] 1. Extraction and purification method of dog liver vegetable polysaccharide

[0018] Weigh 2000g of dry whole grass powder of dog liver dish, add 20000ML petroleum ether to reflux for degreasing and extract for 2 hours, after the medicinal dregs evaporate the petroleum ether, extract with boiling water twice, each time for 1.5 hours, combine the extracts, concentrate to 200 mL, mix with chloroform and The ratio of n-butanol is 4:1, and the Sevag method is used for multiple extractions to obtain a protein-free supernatant, and 95% ethanol is added to make the alcohol content reach 80%, and alcohol precipitation is carried out in a refrigerator at 4°C for 12 hours. Suction filtration, discard the supernatant, and wash the filter residue successively with ether, absolute ethanol, and acetone to obtain the crude polysaccha...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to dicliptera chinensis polysaccharide extracted and purified by using dicliptera chinensis whole herb as a raw material and application of the dicliptera chinensis polysaccharide in preparation of medicines for treating liver injury caused by antituberculosis drugs. The present invention discloses a preparation method of the dicliptera chinensis polysaccharide, and animal experiments prove that the dicliptera chinensis polysaccharide has very good effect on treatment of drug-induced liver injury in mice caused by combined use of antituberculosis drugs isoniazide and rifampicin. The dicliptera chinensis polysaccharide can be applied not only to chemical liver injury, and also has specific effects on tuberculosis drug-induced liver injury; the new application opens up a new area for medicinal value of the dicliptera chinensis polysaccharide, and the dicliptera chinensis polysaccharide has important application value and economic benefit.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to Dicliptera chinensis (L.) Nees. Whole herb as raw material, extracting and purifying polysaccharides from dog liver and its application in the preparation of anti-tuberculosis drugs that cause liver damage. Background technique [0002] dog liver dish Dicliptera chinensis ( L.) Nees. is the whole herb of the genus P. The whole plant is sweet, slightly bitter, and cold in nature. Guixin, liver, and lung meridians have the functions of clearing heat, cooling blood, dampness, detoxification, promoting body fluid, and diuresis. , vomiting of epistaxis, blood in the stool, hematuria, metrorrhagia, cough due to lung heat, sore throat, liver heat and red eyes, conjunctivitis, infantile convulsions, urination, vaginal discharge, herpes zoster, carbuncle, furuncle, snake Dog bite embolism. Dog liver vegetables are very rich in resources, distributed in Yunnan, Guangdong, Gua...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/16C08B37/00
Inventor 高雅张可锋刘笑甫钟明利
Owner GUILIN MEDICAL UNIVERSITY
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