Calcipotriol non-water gel

A technology of calcipotriol and ethanol, which is applied in the direction of medical preparations of non-effective ingredients, organic active ingredients, skin diseases, etc., can solve the problem of complex nanoscale preparation process of solid lipid particles, lack of large-scale industrial technology and conditions, Problems such as poor process reproducibility, to achieve the effect of maintaining system homogeneity or single phase, good drug transdermal performance, and good bioavailability

CN104138352AActive Publication Date: 2014-11-12JIANGSU SEMPOLL PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2014-11-12

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Abstract

A composition for local delivery of calcipotriol is disclosed. The composition comprises (a) not more than 1 wt% of calcipotriol, (b) ethanol, (c) propylene glycol, (d) oleic acid, (e) hydroxy propyl cellulose, (f) glycerol, and (g) 0-5 wt% of water, with the contents being based on the total weight of the composition. The composition has characteristics of high curative effects, low toxicity, stability, capability of guiding or reinforcing delivery of active medicines to skin, and high therapeutic index. The invention also relates to methods of manufacturing and using the composition.
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Description

technical field

[0001] The present invention relates to a topical non-aqueous skin preparation of calcipotriol, which has high curative effect, low toxicity, stability, and can guide or enhance the delivery of active medicine to the skin, thereby obtaining a higher therapeutic index. The invention also relates to methods of making and using the above compositions. technical background

[0002] Calcipotriol is sensitive to light and heat, very easily soluble in 96% alcohol, but extremely insoluble in water (practically insoluble in water, freely soluble inethanol (96 per cent), slightly soluble in methylene chloride.It is sensitive to heat and light .EP5.3), there are ointment varieties on the market, such as the trade name Dalis, its concentration is 0.005% (w / w), suitable for psoriasis vulgaris (psoriasis). However, the molecular weight of calcipotriol is 413 (anhydrous), the molecule is relatively large, and the penetration power is relatively low. The penetration perform...

Examples

Embodiment 1

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Embodiment 2

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Embodiment 3

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