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A kind of quality control method of four-process Cyperus cyperus decoction pieces

A quality control method, the technology of four-made Cyperus cyperus, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to achieve stable quality, controllable process specifications of decoction pieces, lack of quality control methods of modern scientific and technological means, and limited inheritance Problems such as popularization and application, to achieve the effect of improving the pharmacological effect of anti-dysmenorrhea

Active Publication Date: 2016-03-09
江西龙开河中药饮片有限公司
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  • Claims
  • Application Information

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Problems solved by technology

In Jiangxi, Fujian, Taiwan and other surrounding areas, four methods are commonly used to process Cyperus cyperi. The processing technology is unique and enjoys a high reputation in the pharmaceutical industry. However, the processing technology is still mainly based on the inheritance of experience and lacks modern scientific and technological means. The quality control method cannot achieve "stable quality, standardized process, and controllable decoction pieces", which largely limits the inheritance, promotion and application of its unique processing technology

Method used

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  • A kind of quality control method of four-process Cyperus cyperus decoction pieces
  • A kind of quality control method of four-process Cyperus cyperus decoction pieces
  • A kind of quality control method of four-process Cyperus cyperus decoction pieces

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Embodiment 1

[0033] (1) Determination conditions of high performance liquid chromatography:

[0034] Column: DiamonsilC18; Detection wavelength: 250nm; Flow rate: 1.0mL / min; Injection volume: 20μL; Column temperature: room temperature; Mobile phase: methanol and redistilled water; Elution procedure: gradient elution;

[0035] (2) Preparation of reference solution:

[0036] Accurately measure 0.05mL of α-germanone reference substance, place it in a 10mL volumetric flask, dilute to the mark with 95% ethanol, shake well, and obtain a concentration of 5ug / mL reference substance solution;

[0037] (3) The establishment of standard equations:

[0038] Precisely draw the reference substance solution to prepare a series of concentrations, inject it into the liquid chromatograph, analyze the chromatographic conditions in step (1), determine the peak area, take the amount of reference substance as the abscissa and the peak area value as the ordinate to obtain the standard equation y=136.75 x+3.5384, R=0.996....

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Abstract

The invention discloses a quality control method of four-time treated rhizoma cyperi decoction pieces. The quality control method comprises the steps: establishing a four-time treated rhizoma cyperi HPLC fingerprint spectrum, and with an active ingredient alpha-cyperone as a benchmark peak, calculating the content of alpha-cyperone in the benchmark peak; and allowing fingerprint peaks of other main active ingredients to take alpha-cyperone as a reference, calculating the relative contents of the fingerprint peaks of the active ingredients according to alpha-cyperone. The method has operability, can control the relative contents of other unknown main effective ingredients only with the known reference substance alpha-cyperone ingredient content, and is a scientific method achieving control of the quality of the four-time treated rhizoma cyperi decoction pieces. The method is simple, is easy to popularize, reduces the use amount of the reference substance, solves the problems that a market monomeric material reference substance is insufficient and expensive, makes the quality of the four-time treated rhizoma cyperi decoction pieces stable, enhances the pharmacological function, and is conducive to promote rapid development of traditional Chinese medicine industries.

Description

Technical field [0001] The invention relates to the technical field of quality control of traditional Chinese medicines, in particular to a quality control method of four-made Xiangfu decoction pieces. Background technique [0002] Cyperus rotundus L. is the dry rhizome of Cyperus Cyperus. First published in "Famous Doctors", it has the effects of soothing the liver, regulating qi, regulating menstruation and relieving pain. It is an essential medicine for regulating menstruation and relieving pain in gynecology. It is known as "the chief of qi disease and the chief of women’s department". It is clinically used to treat dysmenorrhea, Various gynecological diseases such as menstrual disorders and functional uterine bleeding. Because of the great changes in the pharmacological effects and chemical components of Cyperus rotundus before and after processing, processed products are often used as medicine in clinical practice. [0003] Traditional Chinese medicine processing is an anci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
Inventor 郭慧玲胡律江赵晓娟胡志方李淑雯
Owner 江西龙开河中药饮片有限公司
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