3results about How to "Expensive to solve" patented technology

The invention discloses an engineered adoptive macrophage based on a nano battery as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method disclosed by the invention comprises the following steps: taking an immunologic adjuvant working solution as a raw material, and obtaining nanoparticles with high drug loading capacity through an assembly effect; as the main energy of ChARM comes from an immunologic adjuvant, the high-drug-loading nano-particle is also called a high-energy-density nano-battery. Diluting the obtained nano particles with a cell culture medium, and co-incubating the diluted nano particles and macrophages to obtain engineered macrophages loaded with the anti-tumor or anti-inflammatory nano battery; the assembly mode is any one of supramolecular assembly, prodrug assembly or metal coordination assembly; the high-density drug-loaded nano battery can endow engineered cells with excellent biological functions. The method solves the technical problems that the preparation of the existing CAR-M is expensive, the gene modification is complex, and the nano-drug delivery system is unstable.

The invention provides a high-temperature-resistant GFRP wood composite board based on graphene oxide / MXene multi-dimensional hybrid interface modification and a preparation method and application of the high-temperature-resistant GFRP wood composite board. The composite board is formed by hot-pressing and bonding a wood base body and a modified GFRP reinforcement dispersed in the wood base body through an adhesive. Wherein the modified GFRP reinforcement body is a waste GFRP particle with a multilayer interface structure constructed on the surface, and the structure sequentially comprises a hydroxylation activation layer formed on the surface of the GFRP through alkali treatment, a surface modification layer formed on the surface of the GFRP through alkali treatment, and a surface modification layer formed on the surface of the GFRP through alkali treatment from inside to outside; the amino silane flexible buffer layer is grafted on the hydroxylation anchoring layer; the graphene oxide / MXene nano composite rigid protective layer is adsorbed on the amino silane flexible buffer layer through electrostatic self-assembly. The high-temperature mechanical property of the composite board is remarkably improved, the interface toughness is enhanced, and the utilization rate of MXene in the composite board is high.

This utility model discloses a large-diameter lathe, including a bed, a headstock, a drive system, a cross slide, and a scale. The top of the bed is equipped with longitudinal guide rails; the headstock is fixed to one end of the bed by clamping bolts, and the internal spindle body is supported by bearings and connected to a three-jaw self-centering chuck; the drive system includes a three-phase motor and a frequency converter, driving the spindle through a belt drive mechanism; the cross slide consists of a longitudinal slide and a transverse slide, which are moved by lead screw drives; the bed and slide are equipped with a scale. Vibration damping pads are provided at the headstock connection; the belt drive mechanism includes multi-wedge pulleys and a tension adjustment device; the bed is a welded steel pipe structure filled with damping material. This utility model features low-frequency start-up, energy efficiency, vibration suppression, and high-precision positioning, making it suitable for small and medium-sized enterprises processing large-diameter workpieces.