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Multilayer core-shell nanostructure of gold-organosilicon-gold and its preparation method and application

A nanostructure and organosilicon technology, applied in nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the complex preparation process, poor preparation effect and unstable performance of multilayer core-shell nanostructures and other problems, to achieve excellent photothermal therapy ability, good effect, and not easy to fall off

Active Publication Date: 2017-01-11
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention provides a gold-organosilicon-gold multilayer core-shell nanostructure and its preparation method and application, thereby solving the complex preparation process, poor preparation effect and unstable performance of the multilayer core-shell nanostructure in the prior art And other issues

Method used

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  • Multilayer core-shell nanostructure of gold-organosilicon-gold and its preparation method and application
  • Multilayer core-shell nanostructure of gold-organosilicon-gold and its preparation method and application
  • Multilayer core-shell nanostructure of gold-organosilicon-gold and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0044] At room temperature, mix gold chloride and trisodium citrate at a molar ratio of 25:300, add 72ml of ultrapure water and mix evenly to obtain a bright red colloidal solution, heat the solution to boil and keep it for 15 minutes, then cool down to about 85°C. Continue to add gold chloride and trisodium citrate to the above solution at a molar ratio of 30:75, stir at 85°C for half an hour and then centrifuge to obtain 70ml of dark red colloidal solution dispersed with gold nanoparticles.

[0045] Take 16ml of the above colloidal solution, add 0.2mg of ammonia water and 0.03mg of 3-mercaptopropyltriethoxysilane (MPTES) directly according to the molar ratio of gold nanoparticles, ammonia water and mercaptosilane at 2:300:15, shake for 90s and then let stand for 12h , so as to form a surface mercapto-functionalized intermediate dielectric layer composed of organosilicon on the surface of the gold nanoparticles, thereby obtaining surface-mercapto-functionalized gold-organosili...

Embodiment 2

[0052] At room temperature, mix gold chloride and trisodium citrate at a molar ratio of 25:250, add 72ml of ultrapure water and mix evenly to obtain a bright red colloidal solution, heat the solution to boil and keep it for 15 minutes, then cool down to about 70°C. Continue to add gold chloride and trisodium citrate to the above solution at a molar ratio of 20:100, stir at 70°C for half an hour and then centrifuge to obtain 70ml of dark red colloidal solution dispersed with gold nanoparticles.

[0053] Take 16ml of the above colloidal solution, add 0.2mg of ammonia and 0.04mg of 3-mercaptopropyltriethoxysilane (MPTES) directly according to the molar ratio of gold nanoparticles, ammonia and mercaptosilane at 1:300:20, shake for 90s and let it stand for 12h , so as to form a surface mercapto-functionalized intermediate dielectric layer composed of organosilicon on the surface of the gold nanoparticles, thereby obtaining surface-mercapto-functionalized gold-organosilicon nanoparti...

Embodiment 3

[0058] At room temperature, mix gold chloride and trisodium citrate at a molar ratio of 30:250, add 72ml of ultrapure water and mix evenly to obtain a bright red colloidal solution, heat the solution to boil and keep it for 15 minutes, then cool down to about 90°C. Continue to add gold chloride and trisodium citrate to the above solution at a molar ratio of 40:100, stir at 90°C for half an hour and then centrifuge to obtain 70ml of dark red colloidal solution dispersed with gold nanoparticles.

[0059] After taking 16ml of the above colloidal solution, add 0.2mg of ammonia water and 0.018mg of 3-mercaptopropyltriethoxysilane (MPTES) directly according to the molar ratio of gold nanoparticles, ammonia water and mercaptosilane at a ratio of 6:300:9 and let it stand for 12h after shaking for 90s , so as to form a surface mercapto-functionalized intermediate dielectric layer composed of organosilicon on the surface of the gold nanoparticles, thereby obtaining surface-mercapto-funct...

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Abstract

The invention provides a gold-organic silicon-gold multilayer core-shell nano-structure and a preparing method and application of the multilayer core-shell nano-structure. The multilayer core-shell nano-structure comprises an inner core, a middle dielectric layer and an outer shell, wherein the inner core is made of gold nanoparticles, the middle dielectric layer is made of organic silicon and encircles the inner core, and the outer shell is made of gold nano materials and encircles the middle dielectric layer. The preparing method includes the steps that a, gold chloride and trisodium citrate are used for preparing a colloidal solution where the gold nanoparticles are dispersed; b, ammonia water and sulfydryl silane are added to form the middle dielectric layer made of the organic silicon, and sulfydryl on the surface of the middle dielectric layer is functionalized; c, gold chloride and a reducing agent are added, and a in-situ reduction seed growing method is used for forming the outer shell made of the gold nano materials. The preparing method is simple, efficient and good in repeatability. The multilayer core-shell nano-structure is uniform in appearance and good in monodispersity, has a better photo-thermal effect under irradiation of near-infrared laser compared with a common single-layer gold nano-shell and can serve as an ace enhanced Raman scattering substrate material used for Raman biological imaging.

Description

technical field [0001] The invention relates to the field of nanometer and biomaterials, and more specifically relates to a gold-organosilicon-gold multilayer core-shell nanostructure and its preparation method and application. Background technique [0002] In recent years, gold nanoshells have attracted more and more attention due to their tunable plasmonic optical properties and broad prospects for biomedical and optical applications. Gold nanoshells can generate tunable plasmon resonances, which induce strong optical absorption and scattering. By adjusting the relative size of core and shell (ie core-shell ratio), its extinction peak can span from visible light to near-infrared region (650-1300nm). In order to adjust the plasmon resonance characteristics more finely, a special gold-silica-gold multilayer core-shell nanostructure has been proposed. Theoretically, compared with ordinary single-layer gold nanoshells, multilayer core-shell nanostructures have more complex a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/02B82Y30/00B22F9/24B82Y40/00G01N21/65
Inventor 李永生高勇平王尧施剑林
Owner EAST CHINA UNIV OF SCI & TECH
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