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A kind of paroxetine enteric-coated sustained-release preparation and preparation method thereof

A technology of sustained-release preparations and preparations, applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc.

Active Publication Date: 2019-05-03
BEIJING WINSUNNY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The inventor has developed a kind of paroxetine enteric-coated slow-release preparation through a large number of tests, and this preparation has solved the problem of paroxetine stability and release degree in the above-mentioned paper

Method used

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  • A kind of paroxetine enteric-coated sustained-release preparation and preparation method thereof
  • A kind of paroxetine enteric-coated sustained-release preparation and preparation method thereof
  • A kind of paroxetine enteric-coated sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

9

[0030] Preparation:

[0031] (1) Mix paroxetine hydrochloride and hypromellose and sieve to obtain mixed powder a;

[0032] (2) Evenly mix the mixed powder a with lactose and microcrystalline cellulose to obtain the mixed powder b;

[0033] (3) Povidone is prepared into povidone ethanol solution and added to mixed powder b, granulated and dried;

[0034] (4) Press into tablets, enteric-coated, and the weight gain of the coating is 6-8%.

Embodiment 2

0.65

[0037] Preparation:

[0038] (1) Mix and sieve paroxetine hydrochloride, hypromellose and methylcellulose to obtain mixed powder a;

[0039] (2) Evenly mix the mixed powder a with lactose and microcrystalline cellulose to obtain the mixed powder b;

[0040] (3) Povidone is prepared into povidone ethanol solution and added to mixed powder b, granulated and dried;

[0041] (4) Add magnesium stearate and micronized silica gel;

[0042] (5) Press into tablets, enteric-coated, and the weight gain of the coating is 6-8%.

Embodiment 3

[0044] Element

[0045] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a paroxetine enteric sustained-release preparation and a preparation method thereof. The paroxetine enteric sustained-release preparation comprises a paroxetine tablet core and an enteric coating. The paroxetine tablet core comprises paroxetine or its salt, a hydrophilic gel material, a diluent and a binder. The diluent comprises a mixture of lactose and microcrystalline cellulose or a mixture of lactose and pregelatinized starch. The paroxetine enteric sustained-release preparation has good stability, active components are not influenced by extraneous factors easily, content is not changed basically, a release curve is stable, tablet surface appearance is good, and the preparation method is simple, can be operated easily and is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a paroxetine preparation and a preparation method thereof, in particular to a paroxetine enteric-coated sustained-release preparation and a preparation method thereof. Background technique [0002] Depression is a common mood disorder, which can be caused by various reasons. The main clinical feature is marked and persistent low mood, and the low mood is not commensurate with the situation. In severe cases, suicidal thoughts and behaviors may appear. With the accelerated pace of life and increased stress, the incidence of depression is also on the rise. According to the statistics of the World Health Organization, depression has become the fourth largest disease in the world. It is estimated that by 2020, it may become second only to coronary heart disease. the second leading disease. [0003] Paroxetine was developed by Glaxo with the chemical name (3s)trans-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl ) piperidine,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4525A61K9/28A61K47/26A61K47/38A61K47/36A61P25/22A61P25/24A61P25/00
Inventor 邹文娟郝艳山苏晓峰胡晓虎李泳陈启龙梅喆
Owner BEIJING WINSUNNY PHARMA CO LTD
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