A method for locating and displaying biological gene expression information and environmentally sensitive regions on chromosomes

Abstract

The invention provides a method and system for positioning and displaying biological gene expression information and environment sensitive regions on chromosomes. The method includes: downloading the genome sequence of the biological chromosome; reading in the gene expression chip data of the corresponding biological sample and performing control processing, logarithmic processing and normalization processing to obtain the environmental condition value; comparing the gene name in the gene expression chip data matrix with the downloaded After matching the gene name in the biological chromosome gene sequence, the environmental condition value of the gene is located at the corresponding gene position in the organism genome sequence; according to the located environmental condition value, the gene expression image and the environmental sensitive area on the biological chromosome genome are obtained. The present invention realizes the visualization function of the distribution characteristics of genes with expression changes on chromosomes, can obtain the distribution characteristic data of genes in environmentally sensitive regions, and provides an effective method for analyzing sensitive regions of gene expression changes at the chromosome level and estimating environment-sensitive transcription factors. s help.

Description

technical field [0001] The invention belongs to the technical field of biological information, and relates to a method capable of locating gene expression information on chromosomes and then analyzing sensitive regions of gene expression changes on the chromosomes. Background technique [0002] Gene chip technology uses methods such as photoconductive in-situ synthesis or direct micro-spotting to orderly solidify a large number of DNA fragments or oligonucleotide fragments on the surface of filter membranes, silicon wafers and other supports, and use isotopes or fluorescent molecules to detect samples. After labeling, it is hybridized with the microarray, and the number and sequence information of the sample molecules are obtained by detecting the hybridization signal intensity of each probe molecule. At present, gene chips are mainly used in the detection of gene expression levels, gene diagnosis, drug screening, personalized medicine, sequencing services and bioinformatics...

AI Technical Summary

Problems solved by technology

Although the original C. elegans whole-genome expression data measured by the gene chip has complete gene expression information of C. elegans, it is not sorted according to the corresponding positions of C. elegans genes on the chromosome.

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