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Medicinal titanium metal material and preparation method thereof

A technology of titanium metal and titanium sheet, which is applied in the field of surface modification of biomedical materials, can solve the problem of not being able to provide fixation and growth of osteoblasts, and achieves a solution that is beneficial to fixed growth, improves antibacterial adhesion, and prevents shedding. Effect

Active Publication Date: 2014-12-24
东营市东凯新材料技术研发有限责任公司
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Problems solved by technology

However, this modification method cannot provide the fixation and growth of osteoblasts on the surface of the material.

Method used

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  • Medicinal titanium metal material and preparation method thereof

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preparation example Construction

[0038] A method for preparing a medical titanium metal material, wherein the method comprises the following steps:

[0039] Step 1. Pretreatment: Sonicate the substrate titanium metal with acetone, ethanol and distilled water for 30 minutes in sequence to remove the oil film and oxide film on the surface of the substrate. Both acetone and ethanol can remove the oil film and oxide film on the surface of the substrate. The distilled water is deionized distilled water. It is used as a cleaning agent for cleaning the chemical agent on the surface of the substrate, followed by vacuum drying at 80°C, and then soaking the titanium sheet in an ethanol solution of 5% 3-(methacryloyloxy)propyltrimethoxysilane by volume fraction, soaking 1 hour, washed with distilled water, dried to obtain the treated titanium sheet;

[0040] Step 2: Molecular imprinting combined with surface-initiated atom transfer radical polymerization for surface modification: Add polyethylene glycol methyl ether met...

Embodiment 1

[0046] 1. Product preparation

[0047] Ultrasonic the base titanium metal with acetone, ethanol and distilled water for 30 minutes, vacuum dry at 80°C, and then soak the titanium sheet in an ethanol solution of 3-(methacryloyloxy)propyltrimethoxysilane with a volume fraction of 5% , soaked for 1 hour, washed with distilled water, and dried to obtain a treated titanium metal substrate. Add 80mmol of polyethylene glycol methyl ether methacrylate with a molecular weight of 1000 and 30mmol of ethylene glycol dimethacrylate into 50ml of water and 15ml of ethanol, stir evenly, and add 1mL of osteoblast with a density of 2×104 / ml cells, stir well. The joining area is 1×1cm 2 Titanium sheet, add 0.05mol CuBr, 0.01mol α-bromophenylacetic acid methyl ester, react at 100°C for 30 minutes under the protection of nitrogen. After the reaction, take out the titanium piece, wash it with distilled water, put it into a bottle containing 2ml of 1% type I collagenase, and digest it for 30 seco...

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Abstract

The invention discloses a medicinal titanium metal material and a preparation method thereof. The medicinal titanium metal material has functions of resisting germ sticking and promoting growth of osteoblasts. The medicinal titanium metal material comprises a medicinal metal base body, a first attachment layer and a second attachment layer, wherein the first attachment layer is 3-(methylacryloyl oxygen) propyl triethoxy silane; the second attachment layer is a polyethylene glycol type compound attachment layer. By the introduction of the two attachment layers, the attachment property of a polyethylene glycol type compound to the surface of titanium metal is improved, and falling is prevented; furthermore, the germ sticking resistance capacity of the titanium metal is improved by the polyethylene glycol type compound, and sticking and multiplication of germs on the surface of the titanium metal are avoided. In a process of introducing the polyethylene glycol type compound attachment layer, the titanium metal material has a function of effectively recognizing the osteoblasts by a molecule marking method, so that fixed growth of the osteoblasts on the surface of the material is facilitated.

Description

technical field [0001] The invention relates to the field of surface modification of biomedical materials, in particular to a medical titanium metal material and a preparation method thereof. technical background [0002] With the development of medical technology, medical titanium metal is widely used as implant materials such as dental implants and bone implants in the treatment of dentition defects, bone loss and other diseases, and has played an important role in saving human lives. However, the infection rate of this type of operation is high, which may lead to serious consequences such as heavy antibiotic treatment, removal of implants and even death. There are two main reasons for the high incidence of implant-associated infection: the accumulation of bacterial plaque on the implant surface and the low resistance of the implant osseointegration interface. Therefore, there is a need to improve the antibacterial properties of titanium metal and the function of promotin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/06A61L27/50
Inventor 李培源苏炜霍丽妮陈睿
Owner 东营市东凯新材料技术研发有限责任公司
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