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Medical stainless steel material and preparation method thereof

A technology of stainless steel and adhesion layer, which is applied in the field of surface modification of biomedical materials, can solve the problems of not being able to provide fixation and growth of osteoblasts, and achieve the effects of being conducive to fixation and growth, avoiding adhesion and reproduction, and preventing detachment

Active Publication Date: 2015-01-07
嘉兴慧泉生物科技有限公司
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Problems solved by technology

The modification of the material surface by ethylene glycol compounds is considered to be the most effective method to resist bacterial adhesion, but this modification method cannot provide the fixation and growth of osteoblasts on the material surface

Method used

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  • Medical stainless steel material and preparation method thereof

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preparation example Construction

[0034] A kind of preparation method of medical stainless steel material, wherein, described comprises the following steps:

[0035] Step 1. Pretreatment: After polishing the surface of the stainless steel sheet with silicon carbide sandpaper No. 400 to No. 1000 in sequence, ultrasonically use acetone, ethanol and distilled water for 30 minutes in sequence, vacuum dry at 80°C, and then soak the stainless steel sheet in a solution with a volume fraction of 5% In the ethanol solution of 3-(methacryloyloxy)propyltrimethoxysilane, soak for 1 hour, wash with distilled water, and dry to obtain product 1;

[0036] Step 2, surface grafting polyethylene glycol compound: 2-(2-methoxyethoxy) ethyl methacrylate and CuCl 2 Add water and ethanol, stir evenly, add area 1×1cm 2 For product 1, add CuCl, react at 100°C for 30 minutes under nitrogen protection, and obtain product 2;

[0037] Step 3: Surface modification by molecular imprinting method: add oxalic acid and osteoblasts, stir evenl...

Embodiment 1

[0042]1. Product preparation

[0043] After the surface of the stainless steel sheet was polished sequentially with silicon carbide sandpaper No. 400 to No. 1000, it was ultrasonicated with acetone, ethanol and distilled water for 30 minutes, vacuum-dried at 80°C, and then the stainless steel sheet was soaked in 5% 3-(methyl In the ethanol solution of acryloyloxy)propyltrimethoxysilane, soak for 1 hour, wash with distilled water, and dry to obtain product 1; 1.8mol 2-(2-methoxyethoxy)ethyl methacrylate and 5mmol CuCl 2 Add 50ml of water and 15ml of ethanol, stir evenly, the area of ​​addition is 1×1cm 2 For product 1, add 1.6mmol CuCl, react at 100°C for 30 minutes under the protection of nitrogen to obtain product 2; add 1mol oxalic acid and 5mL osteoblasts with a density of 2×104 / ml, stir well, and react at 100°C for 30 minutes Product 3 was obtained; after the reaction, product 3 was taken out, washed with distilled water, put into a bottle containing 2ml of 1% type I col...

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Abstract

The invention discloses a medical stainless steel material and a preparation method thereof. The medical stainless steel material has the functions of bacterial adhesion resistance and promotion of osteoblast growth and comprises a medical stainless steel matrix, a first adhesive layer and a second adhesive layer, wherein the first adhesive layer is a 3-(methylacryloyloxy) propyltrimethoxysilane adhesive layer; the second adhesive layer is a polyethylene glycol compound adhesive layer. The first adhesive layer is introduced to improve the adhesive capability of the polyethylene glycol compound on the surface of the stainless steel to prevent falling off; the second adhesive layer is introduced to utilize the polyethylene glycol compound to improve the bacterial adhesion resistance of the stainless steel, so as to avoid that the bacteria are adhered and proliferate on the surface of the stainless steel. According to the invention, a molecular imprinting method is utilized during the process that the polyethylene glycol compound adhesive layer is introduced, so as to enable the stainless steel material to achieve a function of effectively identifying the osteoblast molecules and help the osteoblast to be fixed and grow on the surface of the material.

Description

technical field [0001] The invention relates to the field of surface modification of biomedical materials, in particular to a medical stainless steel material and a preparation method thereof. technical background [0002] Medical stainless steel has high hardness, good stability, low cost and good practicability, so it is widely used as implant materials such as dental implants and bone implants in the treatment of dentition defects, bone loss and other diseases. However, the infection rate of this type of operation is high, which may lead to serious consequences such as heavy antibiotic treatment, removal of implants and even death. There are two main reasons for the high incidence of implant-associated infection: the accumulation of bacterial plaque on the implant surface and the low resistance of the implant osseointegration interface. Therefore, there is a need to improve the antibacterial performance of stainless steel. [0003] For bacteria to grow on the surface of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/28A61L27/04A61L27/56C23C22/02
Inventor 李培源苏炜霍丽妮陈睿
Owner 嘉兴慧泉生物科技有限公司
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