Application of cubilose for preparing medicine for protecting intestinal mucosal immune barrier

An immune barrier and intestinal protection technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., to achieve the effect of promoting secretion, improving intestinal mucosal immune regulation, and alleviating intestinal mucosal immune barrier damage

Inactive Publication Date: 2015-01-21
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1986, Ng observed the effect of water extract of bird’s nest on human peripheral mononuclear cells stimulated by ConA or PHA to promote mitosis; in 1989, Jiang Runxiang observed the effect of water extract of bird’s nest in Huaiji on human blood lymphocytes stimulated by ConA to promote mitosis Hou Yan et al. studied the promotion of different varieties of bird's nest on the transformation of rat lymphocytes stimulated by ConA. There are auxiliary effects, and there are certain differences in the auxiliary transformation effects of different types of bird's nests

Method used

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  • Application of cubilose for preparing medicine for protecting intestinal mucosal immune barrier
  • Application of cubilose for preparing medicine for protecting intestinal mucosal immune barrier
  • Application of cubilose for preparing medicine for protecting intestinal mucosal immune barrier

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0012] Example 1 (oral solution)

[0013] 1. Preparation of water-soluble protein

[0014] (1) Take 100g of bird’s nest, add 10000ml of distilled water to soak for 3h, then fully grind and stir;

[0015] (2) Ultrasonic the above-mentioned extract for 10 min, then pass through a 100-mesh sieve to obtain the filtrate;

[0016] (3) Freeze-dry the filtrate to 7% water content to obtain water-soluble protein.

[0017] 2. Preparation of oral liquid

[0018] Mix the water-soluble protein (freeze-dried powder) prepared from the above 100g bird's nest powder with 805g polysorbate, 0.5g stevioside and 2g sodium benzoate, add deionized water to 600ml, and pack into 60 sticks (10ml each), Sterilize, that is.

[0019] Dosage: 3 times a day, 1 stick each time.

example 2

[0020] Example 2 (tablet)

[0021] 1. Preparation of water-soluble protein

[0022] (1) Take 100g of bird’s nest, add 1000ml of distilled water to soak for 6h, then fully grind and stir;

[0023] (2) Ultrasonic the above extract for 40min, then pass through a 100-mesh sieve to obtain the filtrate;

[0024] (3) Freeze-dry the filtrate to 5% water content to obtain water-soluble protein.

[0025] 2. Preparation of tablets

[0026] Mix the water-soluble protein (freeze-dried powder) prepared from the above 100g bird’s nest powder with 10g dextrin and starch to 24g to make granules, dry below 60°C, press into 120 pieces (0.20g / piece), and coat with film. Instantly.

[0027] Dosage: 3 times a day, 2 tablets each time.

example 3

[0028] Example 3 (capsules)

[0029] 1. Preparation of water-soluble protein

[0030] (1) Take 100g of bird’s nest, add 5000ml of distilled water to soak for 4 hours, then fully grind and stir;

[0031] (2) Ultrasound the above-mentioned extract for 30 minutes, then pass through a 100-mesh sieve to obtain the filtrate;

[0032] (3) Freeze-dry the filtrate to 8% water content to obtain water-soluble protein.

[0033] 2. Preparation of capsules

[0034] Mix the water-soluble protein (freeze-dried powder) prepared from the above 100g bird’s nest powder with 10g dextrin and add starch to 30g, spray 40% ethanol to moisten, make granules, dry below 60°C, sieve, and pack into 1 No. capsules, made into 120 hard capsules (0.25g / grain).

[0035] Dosage: 3 times a day, 2 capsules each time.

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Abstract

The invention relates to an application of cubilose for preparing a medicine for protecting an intestinal mucosal immune barrier. By utilizing the medicine of the application, the normal proportion of lymphocytes in intestinal Peyer's patches can be recovered, secretion of intestinal sIgA can be promoted, the intestinal mucosal immune barrier can be protected, and damage of the intestinal mucosal immune barrier caused by chemotherapeutics can be effectively relieved.

Description

technical field [0001] The invention relates to medical preparations, in particular to the new application of bird's nest in the preparation of medicines. Background technique [0002] The bird's nest is a nest built by a variety of birds of the Swift family (APodidae) and the genus Aerodramus (Aerodramus or Collocalia) that secrete saliva and mix with their down feathers and condense on cliffs. Zhang Lu's "Ben Jing Feng Yuan" stated that "Bird's nest, sweet and flat, non-toxic, can produce gold and water, nourish the kidney qi in the lungs, and the stomach qi is also at peace... Today people use it to tonify deficiency and fatigue, cough and spit red phlegm". Modern research has proved that bird's nest has the effects of promoting immunity, promoting mitosis, and anti-virus. Bird's nest contains epidermal growth factor and cell division-promoting component - cell division hormone, which can promote the reproduction and regeneration of human cells, produce the effect of re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/57A61P1/00
CPCA61K9/0053A61K9/08A61K9/4866A61K35/57
Inventor 李耿赖小平
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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