Amide compound, its preparation method, pharmaceutical composition and application
An amide compound and compound technology, which can be applied in the preparation of organic compounds, drug combination, preparation of carboxylic acid amides, etc., can solve problems such as large side effects and poor blood lipid-lowering drug effect.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0177] Embodiment 1: Preparation of amides compound 1-1
[0178] 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionyl chloride 1g, 2-aminoacetophenone 0.4g, triethylamine 0.3g, dichloromethane 60mL in 100mL In a single-necked bottle, react at room temperature for 4 hours, evaporate the solvent to dryness, and obtain 1-11.09 g of the target amide compound by column chromatography, with a yield of 84%. MS (ESI): 436 [M+H + ].
[0179] Amide compounds 1-2 and amide compounds 1-3 can be prepared by a method similar to that described in Example 1 from corresponding raw materials. Amide compound 1-2: MS (ESI): 368[M+H + ]. Amide compounds 1-3: MS (ESI): 479 [M+H + ].
Embodiment 2
[0180] Embodiment 2: the preparation of amides compound 1-1
[0181] 2-methyl-2-(4-(4-chlorobenzoyl)phenoxy)propionic acid 1g, dicyclohexylcarbodiimide 0.57g, 2-aminoacetophenone 0.33g, dichloromethane 60mL Place in a 100mL single-necked bottle, react at room temperature for 4 hours, evaporate the solvent to dryness, and obtain the target amide compound 1-11.12g by column chromatography, with a yield of 82%.
Embodiment 3
[0182] Embodiment 3: the preparation of amides compound 1-4
[0183] 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoyl chloride 1g, 2-amino-(4-bromophenyl)-ethanone 0.79g, triethylamine 0.38g, 60 mL of dichloromethane was placed in a 100 mL single-necked bottle, reacted at room temperature for 4 hours, the solvent was evaporated to dryness, and column chromatography obtained 1-41.35 g of the target amide compound with a yield of 81%. MS (ESI): 446 [M+H + ].
[0184] Amide compounds 1-5 to amide compounds 1-16 can be prepared by a method similar to that described in Example 3 using corresponding raw materials.
[0185] Amide compound 1-5: Yield 83%, MS (ESI): 386[M+H + ].
[0186] Amide compound 1-6: Yield 87%, MS (ESI): 514[M+H + ].
[0187] Amide compounds 1-7: Yield 79%, MS (ESI): 402[M+H + ].
[0188] Amide compounds 1-8: Yield 76%, MS (ESI): 470[M+H + ].
[0189] Amide compounds 1-9: Yield 82%, MS (ESI): 454[M+H + ].
[0190] Amide compounds 1-10: Yield 85%, MS (ES...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle size (mesh) | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More