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Quinolones and sulfonamides residue containing eel matrix standard sample and preparation method thereof

A technology for sulfonamide drugs and standard samples, applied in the field of analytical chemistry, can solve the problems that the test results are not convincing, the drug extraction efficiency cannot be truly reproduced, and the method accuracy cannot be reflected, so as to achieve easy preservation and test data. Reliable, accurate and stable

Inactive Publication Date: 2015-02-18
INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, domestic residue analysis laboratories are often unable to obtain actual contaminated samples, and sulfonamides and quinolones are two different drugs, which have different natural metabolism mechanisms in aquatic products and different extraction efficiencies. Therefore, laboratory testing often It is necessary to add different compound standard solutions to the analysis samples at the same time for quality control, which cannot truly reproduce the extraction efficiency of the drug in animals after natural metabolism, cannot reflect the accuracy of the method, and the obtained test results are not enough to make convincing

Method used

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  • Quinolones and sulfonamides residue containing eel matrix standard sample and preparation method thereof
  • Quinolones and sulfonamides residue containing eel matrix standard sample and preparation method thereof
  • Quinolones and sulfonamides residue containing eel matrix standard sample and preparation method thereof

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Embodiment 1

[0034] (1) Preparation of natural pollution samples

[0035] The eel samples were cultured in tanks. The water tank has an area of ​​150 square meters, a depth of 1.5 meters, and a drain hole. The water tank is placed in the shade, the culture temperature is kept at 20°C, the oxygen is increased by the circulating water pump, and the daily water exchange rate is 100%. The size of the cultured eels in this water tank is 150 grams per contract, and the total amount of cultured is 18 kilograms. Weigh the veterinary drugs enrofloxacin, ciprofloxacin, norfloxacin, ofloxacin, oxolinic acid and flumequine, as well as sulfamethazine and sulfamethoxine. The concentrations of the above drugs are as follows 1:

[0036]

[0037] Weigh an appropriate amount of the above-mentioned drugs, first dissolve the drugs with about 50 mL of water, and then gradually dilute them into the aquaculture tank. Make the drug concentration 1.0 mg / L; start to stop using the drug on the second day afte...

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Abstract

The invention belongs to the field of analytical chemistry and in particular relates to a quinolones and sulfonamides residue containing eel matrix standard sample and a preparation method thereof. Enrofloxacin, ciprofloxacin, norfloxacin, ofloxacin, oxolinic acid, flumequine, sulfadimidine and sulfamonomethoxine are administrated into an eel culture pond in a splashing manner; stopping drugs after administrating on the second day, cleaning the pond, changing into clean water for cultivation; taking the eels out after administrating on the fifth day, slaughtering, removing heads, bloodletting, removing internal organs and fish skins and cryo-preserving in an ice tank at below 18 DEG C; and then carrying out irradiation treatment for prolonging the storage life of the sample. The matrix standard sample has good uniformity and good stability, can be stored easily, and can be used conveniently, the sampling amount and the extraction and purification methods are the same as those of the routine analysis sample, the detection data is reliable and accurate even if at different environment temperature at different times by different detectors, and the matrix standard sample can be used as a quality control measure in the detection work and has application and promotion values.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to a standard sample of an eel matrix containing quinolones and sulfonamide drug residues and its preparation. Background technique [0002] Sulfonamide drugs refer to the general term of a class of drugs with p-aminobenzenesulfonamide structure, which is a class of chemical drugs used to prevent and treat bacterial infection diseases. Since 1932, thousands of sulfa drugs have been synthesized, among which there are dozens of sulfa drugs with good curative effect, low toxicity and side effects. Quinolones belong to pyruvate derivatives, which are the most important breakthrough in the synthesis of antibiotics after sulfonamides. Quinolones have wide antibacterial spectrum, high efficiency and low toxicity, and have become one of the most important anti-infective drugs in veterinary medicine. [0003] However, sulfonamides and quinolones have different degrees of tox...

Claims

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Application Information

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IPC IPC(8): G01N1/44
Inventor 杨方刘正才
Owner INSPECTION & QUARANTINE TECH CENT OF FUJIAN ENTRY EXIT INSPECTION & QUARANTINE BUREAU
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