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Processing technology for cefcapene pivoxil hydrochloride

A technology of cefcapine hydrochloride and processing technology, applied in the field of medicine, can solve the problem of no cefcapine hydrochloride processing technology, etc., and achieve the effects of good stability, uniform color and good quality

Inactive Publication Date: 2015-02-25
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For how to process a good quality cefcapene pivoxil hydrochloride preparation, there is almost no relevant report on the processing technology of cefcapene pivoxil hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The processing technique of cefcapene pivoxil hydrochloride comprises the following steps:

[0021] (6) Dry raw materials and auxiliary materials so that the moisture content of raw materials and auxiliary materials is ≤3.0%;

[0022] (7) Sieve the raw materials and auxiliary materials through 100 mesh;

[0023] (8) Mix raw materials and auxiliary materials;

[0024] (9) Make granules from raw materials and auxiliary materials that have been processed by powder mixing, and control the moisture content of finishing to ≤3.6%;

[0025] (10) Coating after tableting.

[0026] The particle size of the whole grain in the step (4) is 40 mesh.

[0027] The coating is to heat the tablet core in a coating pot, the temperature of the air inlet is 75° C., and the speed of the coating pot is 4 rpm.

[0028] The exhaust air temperature of the coating is 30°C.

[0029] The coating temperature is 35°C.

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PUM

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Abstract

The invention discloses a processing technology for cefcapene pivoxil hydrochloride. The processing technology comprises the steps that firstly, raw materials and auxiliary materials are dried, and the water content of the raw materials and the water content of the auxiliary materials are made to be lower than or equal to 3.0%; the raw materials and the auxiliary materials are screened through a 100-mesh screen and then mixed, dry granulation is conducted, tabletting is conducted, and products are obtained after coating is conducted. By means of the processing technology, the pharmaceutical preparation good in quality and stability, smooth in tablet face and even in color can be obtained.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a processing technology of cefcapene hydrochloride. Background technique [0002] Cefcapene pivoxil hydrochloride is used for the treatment of superficial infection caused by sensitive bacteria, deep skin infection, chronic pyoderma, secondary infection of wounds such as trauma, scald and surgical trauma, mastitis, thick around the anus, pharyngitis, laryngitis, Dental tissue infection, periodontitis, etc. At present, cefcapene hydrochloride is generally used in tablets because of the convenience of oral administration. However, cefcapene pivoxil hydrochloride is slightly soluble in ethanol and almost insoluble in water. How to improve its solubility and increase the dissolution rate of tablets has always been a subject of close attention in pharmaceutical preparations. [0003] For how to process and finish the preparation of a good quality cefcapene pivoxil hydrochloride, there is alm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/10A61K9/28A61K31/546A61P31/04
Inventor 沈千万周璇刘萍
Owner SICHUAN PHARMA
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